{"id":"W4414070923","doi":"10.5267/j.ccl.2025.8.002","title":"N-(5-(Dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfonamides: Small molecules with big synthetic capabilities","year":2025,"lang":"en","type":"article","venue":"Current Chemistry Letters","topic":"Synthesis and Characterization of Heterocyclic Compounds","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Enamine","keywords":"Small molecule; Alkyl; Hydrolysis; Aryl; Molecule; Reaction conditions","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002345297,0.0004897504,0.0002316458,0.0002011153,0.0001143205,0.0001881835,0.000303416,0.0002625633,0.00126317],"category_scores_gemma":[0.0001388947,0.000133919,0.0001424658,0.0001551722,0.0002400807,0.0002200816,0.0002476441,0.0003386035,0.0006567211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003402541,"about_ca_system_score_gemma":0.0002391217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004438755,"about_ca_topic_score_gemma":0.0007756574,"domain_scores_codex":[0.9998835,0.00002484296,0.00001000571,0.00002399512,0.00002630407,0.00003121228],"domain_scores_gemma":[0.9999042,0.00001666392,0.0000331051,0.000009506231,0.00001202835,0.00002447404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000117231,0.00002051043,0.0001773571,0.0001420599,0.000006016057,0.0001031477,0.0000317604,0.0001483977,0.9924543,0.0006644699,0.0001098651,0.006024906],"study_design_scores_gemma":[0.00005472882,0.0007250442,0.001760354,0.00001042068,0.00001793685,0.0005241248,0.00002739011,0.0007258946,0.977353,0.00009107384,0.01869402,0.00001594082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9267234,0.02018191,0.03614066,0.0003108425,0.0001364011,0.0001662335,0.0005765262,0.0005318842,0.01523206],"genre_scores_gemma":[0.9783043,0.004553321,0.01176201,0.00009790638,0.00003211958,0.0001300202,0.000371934,0.00001998127,0.004728429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00126317,"threshold_uncertainty_score":0.004225731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01379536657379568,"score_gpt":0.2227818068006377,"score_spread":0.208986440226842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}