{"id":"W4414075106","doi":"10.1016/j.toxlet.2025.07.986","title":"P32-12 In vitro Skin Sensitization Potency Assessment Using GARD®skin Dose-Response: A Case study on Natural Extracts-Based Skin-Binding Dyes and Dye Precursors","year":2025,"lang":"en","type":"article","venue":"Toxicology Letters","topic":"Skin Protection and Aging","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"SKiN Health","funders":"","keywords":"Potency; Skin sensitization; Sensitization; In vitro; In vivo; In vitro toxicology; Local lymph node assay","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006239774,0.0004253551,0.0003265021,0.0003325634,0.0003433049,0.0003845499,0.0002975678,0.0007481834,0.00129641],"category_scores_gemma":[0.0004227712,0.0001629956,0.0004876974,0.0003097571,0.0003186702,0.0002839516,0.00030889,0.0004193544,0.0004113653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002071518,"about_ca_system_score_gemma":0.0001913174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008541336,"about_ca_topic_score_gemma":0.001808288,"domain_scores_codex":[0.999446,0.0001781717,0.000028354,0.0001070704,0.000181464,0.00005891542],"domain_scores_gemma":[0.9996124,0.0001467174,0.00005102409,0.00005986509,0.0001026852,0.00002735515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002506821,0.0003705717,0.001621085,0.0001934075,0.0000124583,0.0006740538,0.0002063388,0.0005969926,0.9903251,0.00009164949,0.00005810975,0.005599558],"study_design_scores_gemma":[0.000005657776,0.005315725,0.004647661,0.00001533058,0.00003376994,0.0009718385,0.0002560141,0.001140133,0.9860328,0.00006420269,0.001506109,0.0000108342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895616,0.001260336,0.005786636,0.00005265871,0.00002307575,0.0001823939,0.0001576008,0.00004078843,0.002934809],"genre_scores_gemma":[0.9906723,0.001154817,0.004526734,0.00004248185,0.000007017996,0.00003330488,0.00008820148,0.00001660677,0.003458646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00129641,"threshold_uncertainty_score":0.004336894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01973189061432141,"score_gpt":0.3418941168917172,"score_spread":0.3221622262773958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}