{"id":"W4414079907","doi":"10.1101/2025.09.05.674255","title":"Enhancers mediate euchromatin hopping at chromatin contact points","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Hospital for Sick Children","keywords":"Euchromatin; Chromatin; Enhancer; Heterochromatin; Enhancer RNAs; Histone; ChIA-PET; Nucleosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001870897,0.0003928787,0.0003045076,0.0003205222,0.0001902059,0.0005629481,0.0005020553,0.0003709633,0.01470537],"category_scores_gemma":[0.0003233357,0.0002914651,0.0004059482,0.0003177801,0.0002628431,0.0005637847,0.0005764356,0.0007227352,0.001781585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004022505,"about_ca_system_score_gemma":0.0001781023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007789785,"about_ca_topic_score_gemma":0.0008033082,"domain_scores_codex":[0.9998386,0.00001847956,0.000005325526,0.00006133962,0.00004061302,0.00003552192],"domain_scores_gemma":[0.9998494,0.00003933641,0.00005210168,0.00002163945,0.00001488583,0.00002255722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007450114,0.00008143864,0.006800082,0.002370968,0.0001869999,0.0005399998,0.0002680755,0.02650078,0.8624415,0.03637001,0.01095233,0.0527428],"study_design_scores_gemma":[0.0001692821,0.0004416491,0.02818457,0.0002183898,0.0002029103,0.0008667703,0.0003630638,0.08923514,0.7771122,0.03014971,0.07295443,0.0001020157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7372467,0.007916806,0.2002759,0.001176474,0.0004146599,0.0002200552,0.01419355,0.007100221,0.03145572],"genre_scores_gemma":[0.9832768,0.000882218,0.009159034,0.00008453745,0.0000164156,0.00003864288,0.002139698,0.0001064741,0.004296058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01470537,"threshold_uncertainty_score":0.04919434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006480437592808544,"score_gpt":0.2108876898283643,"score_spread":0.2044072522355558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}