{"id":"W4414082275","doi":"10.1200/jco-25-00788","title":"Phase II Dose-Randomized Study of Sunvozertinib in Platinum-Pretreated Non–Small Cell Lung Cancer With Epidermal Growth Factor Receptor Exon 20 Insertion Mutations (WU-KONG1B)","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Epidermal growth factor receptor; Lung cancer; Exon; Tyrosine kinase; Adverse effect; Mutation; Gefitinib; Tyrosine-kinase inhibitor; Kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002235116,0.001570652,0.002108848,0.0003538413,0.0004013951,0.0008356901,0.0008701605,0.001218248,0.004311266],"category_scores_gemma":[0.00144139,0.0007357281,0.00134657,0.0003286081,0.0009530041,0.000761023,0.000382301,0.002700714,0.0009111219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001054511,"about_ca_system_score_gemma":0.001798103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009372825,"about_ca_topic_score_gemma":0.003838488,"domain_scores_codex":[0.9991541,0.0005222457,0.00003277585,0.0001291415,0.00006082478,0.000100857],"domain_scores_gemma":[0.9991814,0.0001516255,0.0001981485,0.00009028107,0.00005670227,0.0003217452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9296884,0.02918721,0.002040843,0.0003929584,0.001097767,0.00004913224,0.0001191303,0.001571294,0.009530745,0.0002902682,0.002612842,0.02341949],"study_design_scores_gemma":[0.9209958,0.07411242,0.002060252,0.00001256577,0.00020694,0.00003752512,0.00001993387,0.0008154913,0.0007718285,0.0002044848,0.0007500133,0.00001279507],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849706,0.00127939,0.00113861,0.0005160413,0.0003010516,0.007829194,0.00153503,0.0001597457,0.002270416],"genre_scores_gemma":[0.9815669,0.0009933801,0.00267555,0.001277574,0.0002138107,0.007890654,0.001701803,0.00004189572,0.003638472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004311266,"threshold_uncertainty_score":0.0144226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05783105348473801,"score_gpt":0.4737976776117332,"score_spread":0.4159666241269953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}