{"id":"W4414084284","doi":"10.1093/molehr/gaaf046","title":"Meta-analysis examining fetal sex-specific placental DNA methylation intensities and estimated cell composition post IVF","year":2025,"lang":"en","type":"article","venue":"Molecular Human Reproduction","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University Medical Centre; McMaster University; Hamilton Health Sciences","funders":"","keywords":"Syncytiotrophoblasts; DNA methylation; Fetus; Population; Methylation; Placenta; Cell-free fetal DNA; Epigenetics; Population stratification","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007691021,0.001404716,0.004884622,0.002104913,0.0006955807,0.001895934,0.001699379,0.001529911,0.003171786],"category_scores_gemma":[0.02603832,0.0008881459,0.02264573,0.003791917,0.0004152742,0.0008945522,0.001046921,0.001597553,0.0002798767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008145793,"about_ca_system_score_gemma":0.0009577003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009028343,"about_ca_topic_score_gemma":0.01041398,"domain_scores_codex":[0.9925855,0.003874775,0.0009092857,0.001816875,0.00047643,0.0003371626],"domain_scores_gemma":[0.984561,0.01186405,0.001230225,0.001517667,0.0006101936,0.0002168821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.007547762,0.00003477128,0.2238796,0.01782345,0.7264284,0.0003340638,0.0001513397,0.002380288,0.001586261,0.0003417077,0.001963659,0.01752869],"study_design_scores_gemma":[0.0005912381,0.0004414802,0.1802244,0.002441767,0.8076972,0.0004305888,0.0001416555,0.002379374,0.0009127377,0.0008722642,0.00381913,0.00004818952],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2858555,0.6848603,0.01067358,0.001554924,0.0007617812,0.0001719136,0.01390221,0.0002696457,0.00195013],"genre_scores_gemma":[0.9597734,0.03272168,0.002423292,0.0006937023,0.000195094,0.0002414914,0.003230327,0.00009995198,0.00062112],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.009028343,"threshold_uncertainty_score":0.04067451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06390001596902266,"score_gpt":0.2995863080276732,"score_spread":0.2356862920586505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}