{"id":"W4414085038","doi":"10.1097/ju.0000000000004732","title":"Reply: A Randomized Phase 3 Trial of Metformin in Patients Initiating Androgen Deprivation Therapy as Prevention and Intervention of Metabolic Syndrome: The PRIME Study","year":2025,"lang":"en","type":"article","venue":"The Journal of Urology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; Saskatchewan Cancer Agency; University of Alberta","funders":"","keywords":"Metformin; Androgen deprivation therapy; Intervention (counseling); Randomized controlled trial; Prime (order theory); Androgen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009872683,0.001141869,0.002699553,0.0006566613,0.001228103,0.001979484,0.002293753,0.01744968,0.005389512],"category_scores_gemma":[0.03627918,0.0006949221,0.002686056,0.000864481,0.001543186,0.001952327,0.001015948,0.02294935,0.002356997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001810424,"about_ca_system_score_gemma":0.003080104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005194146,"about_ca_topic_score_gemma":0.00639275,"domain_scores_codex":[0.9969568,0.001626337,0.0004539515,0.0003806574,0.000330992,0.0002512283],"domain_scores_gemma":[0.9806854,0.01464876,0.00101018,0.0005206351,0.0021555,0.0009795696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.00950472,0.0002081586,0.002949734,0.001322577,0.001122211,0.0004955705,0.0001598701,0.0002700332,0.0005334129,0.001284816,0.9612166,0.02093237],"study_design_scores_gemma":[0.05402396,0.003417107,0.02150207,0.003063476,0.0092254,0.001524133,0.001063914,0.002471095,0.002553247,0.01277147,0.8878021,0.0005820805],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.003234747,0.006393515,0.0002672515,0.9203099,0.06749468,0.0001422383,0.001345896,0.00005960286,0.0007523046],"genre_scores_gemma":[0.009800732,0.002148385,0.000484512,0.9453797,0.03936571,0.0002517187,0.0002815317,0.0000245143,0.002263115],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01744968,"threshold_uncertainty_score":0.05221242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01152157585627842,"score_gpt":0.3109894263721892,"score_spread":0.2994678505159107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}