{"id":"W4414090383","doi":"10.1038/s41586-025-09502-0","title":"Molecular subtypes of human skeletal muscle in cancer cachexia","year":2025,"lang":"en","type":"article","venue":"Nature","topic":"Nutrition and Health in Aging","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Cancer Foundation; University of Alberta","funders":"","keywords":"Skeletal muscle; microRNA; Muscle atrophy; Extracellular matrix; Gene expression; Wasting; Muscle disorder; Induced pluripotent stem cell; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003852656,0.0002243975,0.0002471407,0.0009290335,0.0002859325,0.0003773416,0.0003700948,0.0003084327,0.00254254],"category_scores_gemma":[0.0001976735,0.0001982749,0.0003673305,0.0005889972,0.0002232694,0.0002999833,0.0003284909,0.0003140174,0.0003884894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002488426,"about_ca_system_score_gemma":0.0001988964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00223342,"about_ca_topic_score_gemma":0.002951598,"domain_scores_codex":[0.9998734,0.00003258233,0.00001273409,0.00002660069,0.00002780737,0.00002688585],"domain_scores_gemma":[0.9999065,0.00001457868,0.00002960883,0.000008720818,0.00002339441,0.00001725387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004547568,0.0001149673,0.06314705,0.0006243958,0.0003047287,0.0008720103,0.0005201576,0.0003726164,0.8750282,0.004184931,0.001645701,0.04863778],"study_design_scores_gemma":[0.0002889555,0.001689766,0.8585345,0.0003306645,0.0003474117,0.006103744,0.002208415,0.001254493,0.08680648,0.003262092,0.03913236,0.00004113129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9530391,0.03273582,0.001840981,0.00067932,0.00008759298,0.00008048263,0.001305863,0.00003314379,0.01019778],"genre_scores_gemma":[0.9750117,0.01065159,0.001820854,0.0002483007,0.00006308129,0.00008532261,0.002003722,0.00001634026,0.01009899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00254254,"threshold_uncertainty_score":0.008505583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0152956533522881,"score_gpt":0.3833310953979892,"score_spread":0.3680354420457011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}