{"id":"W4414091396","doi":"10.3390/biom15091304","title":"A Comprehensive Oncological Biomarker Framework Guiding Precision Medicine","year":2025,"lang":"en","type":"review","venue":"Biomolecules","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Queen's University","funders":"Roswell Park Cancer Institute","keywords":"Precision medicine; Biomarker; Immunotherapy; Personalized medicine; Liquid biopsy; Microbiome; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003460798,0.0007046756,0.002792919,0.0006232455,0.0001362289,0.00003365472,0.0003805215,0.001087421,0.0007052069],"category_scores_gemma":[0.0005143629,0.0004392766,0.001005702,0.001322077,0.0005956304,0.00002826638,0.0002098435,0.0003657088,0.00007956645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003821616,"about_ca_system_score_gemma":0.0006081156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004609283,"about_ca_topic_score_gemma":0.000001811656,"domain_scores_codex":[0.996793,0.0003197558,0.001105098,0.0008199788,0.0005179411,0.0004441665],"domain_scores_gemma":[0.9970581,0.001388429,0.0003973681,0.000801121,0.0001747765,0.0001802331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003710278,0.0001100836,0.000001711734,0.01528721,0.000765359,0.0002212801,0.00002752592,5.325022e-9,0.0001896312,0.0003258379,0.02321697,0.9594834],"study_design_scores_gemma":[0.0008003776,0.0004649411,0.00003245873,0.1084579,0.001510244,0.0002337584,0.0000413253,0.000001516659,0.00001619111,0.0001497263,0.8879352,0.0003563619],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000006072436,0.9896146,0.001282128,0.0008048447,0.001104307,0.001665028,0.00004918956,0.0001657377,0.005308064],"genre_scores_gemma":[0.0000108661,0.9942156,0.002442615,0.001087885,0.0004120216,0.0001567985,0.0002787261,0.00005742912,0.001338038],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.959127,"threshold_uncertainty_score":0.9998059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1573413837309701,"score_gpt":0.4366868579186391,"score_spread":0.279345474187669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}