{"id":"W4414091396","doi":"10.3390/biom15091304","title":"A Comprehensive Oncological Biomarker Framework Guiding Precision Medicine","year":2025,"lang":"en","type":"review","venue":"Biomolecules","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Queen's University","funders":"Roswell Park Cancer Institute","keywords":"Precision medicine; Biomarker; Immunotherapy; Personalized medicine; Liquid biopsy; Microbiome; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003014972,0.001374857,0.001586064,0.002698474,0.0004339053,0.002473974,0.00136971,0.002381274,0.002015967],"category_scores_gemma":[0.003148087,0.0003790176,0.0008616048,0.001559211,0.001309681,0.002672343,0.001677294,0.003024018,0.001244889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001843613,"about_ca_system_score_gemma":0.003743864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001473966,"about_ca_topic_score_gemma":0.001987682,"domain_scores_codex":[0.9991409,0.0002849524,0.00009494687,0.0001219442,0.0002890575,0.00006817147],"domain_scores_gemma":[0.9984274,0.0008709396,0.0001405314,0.00006172227,0.000417074,0.00008233778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006210027,0.00008043096,0.0004450616,0.0178117,0.0002519639,0.0002818651,0.0001972773,0.001537416,0.002646905,0.08638426,0.03086998,0.859431],"study_design_scores_gemma":[0.00001268064,0.0001018564,0.0006102742,0.008383276,0.000187947,0.0006991548,0.0001224881,0.0005799841,0.001002639,0.03131656,0.9569452,0.00003782126],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002278403,0.9887551,0.003615379,0.003932731,0.0006454997,0.00002623112,0.00006100949,0.00003512637,0.002701146],"genre_scores_gemma":[0.005131136,0.9848531,0.00594958,0.002165418,0.0007216585,0.00005225898,0.0001096058,0.000007599087,0.001009614],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003014972,"threshold_uncertainty_score":0.01594484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1573413837309701,"score_gpt":0.4366868579186391,"score_spread":0.279345474187669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}