{"id":"W4414095915","doi":"10.1097/ju9.0000000000000344","title":"Metastatic Squamous Cell Carcinoma of Prostatic Origin: Identification Through Next Generation Sequencing and Treatment With Pembrolizumab: A Case Report","year":2025,"lang":"en","type":"article","venue":"JU Open Plus","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke","funders":"","keywords":"Prostatic adenocarcinoma; Adenocarcinoma; Prostate cancer; DNA sequencing; Radiation therapy; Prostate; Carcinoma; Pembrolizumab; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003844507,0.001544478,0.00121132,0.002150812,0.002973426,0.00202853,0.0009495544,0.005175736,0.001752189],"category_scores_gemma":[0.001923815,0.001149325,0.001264143,0.001426235,0.001532851,0.001852236,0.001265023,0.003498713,0.000833174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001297295,"about_ca_system_score_gemma":0.0008408217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002843071,"about_ca_topic_score_gemma":0.004081188,"domain_scores_codex":[0.9994216,0.00006552484,0.00005749592,0.0001521592,0.0001357884,0.0001674369],"domain_scores_gemma":[0.998848,0.0002872089,0.0002273117,0.00008742468,0.00007774911,0.0004723069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00001963734,0.00004113782,0.003811672,0.00003150025,0.00001222777,0.9935594,0.0001816263,0.00006422748,0.0005581734,0.0001296783,0.000265768,0.001324933],"study_design_scores_gemma":[0.000003895895,0.00002961421,0.002000322,0.00001122568,0.00001330086,0.9967878,0.00008285747,0.0002524947,0.0003450196,0.00008933144,0.0003764114,0.000007756872],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.961939,0.01008788,0.008143604,0.006013961,0.0005570413,0.0002672804,0.0003208632,0.0002670149,0.01240324],"genre_scores_gemma":[0.9895705,0.003532804,0.002747719,0.001221442,0.0009843826,0.00002680685,0.0001083832,0.00003559937,0.001772333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005175736,"threshold_uncertainty_score":0.009412587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1395206772410934,"score_gpt":0.3775446138727638,"score_spread":0.2380239366316703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}