{"id":"W4414106759","doi":"10.1016/j.autrev.2025.103934","title":"The effect of Sphingosine-1-phosphate receptor modulator treatment on leukocyte subsets across different clinical indications: A systematic review","year":2025,"lang":"en","type":"review","venue":"Autoimmunity Reviews","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"H2020 Marie Skłodowska-Curie Actions; Horizon 2020 Framework Programme; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Alexander S. Onassis Public Benefit Foundation; ZonMw; European Commission","keywords":"Receptor; Inflammation; Pharmacodynamics; Lymph; Inflammatory response; Gene isoform","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005806188,0.0009885876,0.00714885,0.00006427785,0.0004473924,0.00007140332,0.00138005,0.0005028697,0.00001230823],"category_scores_gemma":[0.004884906,0.0004870969,0.003058808,0.0004238356,0.0002086198,0.000005894812,0.0003531681,0.0005598183,0.000100948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001149383,"about_ca_system_score_gemma":0.0002841828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002115537,"about_ca_topic_score_gemma":0.000005643992,"domain_scores_codex":[0.9887466,0.006120296,0.003656765,0.0007081879,0.0002872396,0.0004808773],"domain_scores_gemma":[0.9923328,0.001343389,0.002857151,0.003241882,0.00009647636,0.0001282668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002179576,0.0001001011,0.00000569917,0.5863779,0.0006298284,5.016746e-7,0.00001326109,1.309721e-7,0.00001471198,0.00002269324,0.0005665211,0.4122469],"study_design_scores_gemma":[0.0003156791,0.0004090025,0.000004971695,0.3879336,0.003307498,0.000005206229,0.0000019186,8.40294e-7,0.0002150248,9.011297e-7,0.6075338,0.0002715744],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004308695,0.9895621,0.00002249405,0.00002179602,0.0007297604,0.009053391,0.0001143158,0.00002354189,0.00004174369],"genre_scores_gemma":[0.00005801085,0.9947547,0.00002361709,0.0001573354,0.0001605829,0.002983415,0.0008614617,0.00006324454,0.0009375893],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6069672,"threshold_uncertainty_score":0.9997581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04184363224272554,"score_gpt":0.4002690041797873,"score_spread":0.3584253719370618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}