{"id":"W4414111446","doi":"10.1016/j.celrep.2025.116263","title":"Cryo-EM structure of a type VI secretion system-delivered membrane-depolarizing toxin involved in bacterial antagonism","year":2025,"lang":"en","type":"article","venue":"Cell Reports","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Institute of Infection and Immunity; Canadian Institutes of Health Research; Rijksuniversiteit Groningen; Netherlands Centre for Electron Nanoscopy; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Universiteit Leiden; Burroughs Wellcome Fund","keywords":"Effector; Secretion; Type VI secretion system; Mutagenesis; Cytoplasm; Toxin; Protein structure; Antagonism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001657492,0.0004291461,0.0002323182,0.0002211324,0.0008583802,0.0003979738,0.0007525389,0.0009993912,0.00370217],"category_scores_gemma":[0.0002714761,0.0002868295,0.0003166618,0.0002943927,0.0004987695,0.000586518,0.0003963161,0.001683698,0.0006555148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009465601,"about_ca_system_score_gemma":0.0004703084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004819021,"about_ca_topic_score_gemma":0.004344943,"domain_scores_codex":[0.999956,0.000005948828,0.000002172817,0.000008377599,0.00001487507,0.00001265857],"domain_scores_gemma":[0.9998747,0.00003502066,0.00002053985,0.000008508559,0.00002374362,0.00003751336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00213159,0.0006586072,0.009852876,0.001176894,0.0002177298,0.007839251,0.001233077,0.03496163,0.9076892,0.006414211,0.01650791,0.01131694],"study_design_scores_gemma":[0.0004905944,0.002013696,0.2242849,0.0007732782,0.000446983,0.01027835,0.003486137,0.292055,0.384235,0.005183959,0.07646806,0.0002839802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9664761,0.003157259,0.011172,0.002086091,0.000227829,0.00005774802,0.002622727,0.0004003216,0.01379992],"genre_scores_gemma":[0.9736915,0.002868695,0.01257989,0.0005190587,0.00004995803,0.00005927121,0.005232726,0.0001405907,0.004858519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004819021,"threshold_uncertainty_score":0.01238495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007492483634042284,"score_gpt":0.242716309391711,"score_spread":0.2352238257576688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}