{"id":"W4414111578","doi":"10.1016/j.celrep.2025.116245","title":"Integrative analysis of taste genetics and the dental plaque microbiome in early childhood caries","year":2025,"lang":"en","type":"article","venue":"Cell Reports","topic":"Biochemical Analysis and Sensing Techniques","field":"Nursing","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Canadian Institutes of Health Research; Manitoba Centre for Health Policy, University of Manitoba; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; University of Manitoba","keywords":"Early childhood caries; Streptococcus mutans; Microbiome; Oral Microbiome; Dental plaque; Genotype; Taste; Disease; Bitter taste","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002060126,0.0001010568,0.0003674303,0.0002599178,0.0000427691,0.00003405036,0.00005942125,0.00007992108,0.000003288361],"category_scores_gemma":[0.00004692757,0.00006442737,0.0001523894,0.0007866353,0.0002807474,0.00001824028,0.00006260505,0.0001234813,9.368437e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002687228,"about_ca_system_score_gemma":0.00001414884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009018395,"about_ca_topic_score_gemma":0.0004932851,"domain_scores_codex":[0.9991463,0.00006277853,0.0003961773,0.0002137299,0.0000791511,0.0001018466],"domain_scores_gemma":[0.9994163,0.00007821104,0.0001806865,0.0002519365,0.00005465739,0.00001818934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003089902,0.0004540417,0.3932089,0.00008251033,0.00194544,0.0001451407,0.01797774,0.00006707408,0.5767062,0.0005643123,0.002134754,0.00640493],"study_design_scores_gemma":[0.0002570233,0.00002747329,0.07484724,0.00007404338,0.001329003,0.00001134973,0.0005316723,0.0005122139,0.9197674,0.0023181,0.0002104915,0.000113943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969429,0.001229619,0.0001700823,0.0002641968,0.00005650551,0.0001203292,0.000004149511,0.00001565858,0.001196499],"genre_scores_gemma":[0.9990865,0.00004199052,0.0006155374,0.0001018201,0.00000615564,0.000002440865,0.00001785211,0.000004357552,0.0001233698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3430613,"threshold_uncertainty_score":0.2627272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003237649702031675,"score_gpt":0.2188140262513109,"score_spread":0.2155763765492792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}