{"id":"W4414118670","doi":"10.1016/j.neurot.2025.e00737","title":"Antibody targeting TDP-43 mitigates pathogenic pathways induced by the cerebrospinal fluid of ALS","year":2025,"lang":"nl","type":"article","venue":"Neurotherapeutics","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Bombardier (Canada)","funders":"Canadian Institutes of Health Research; ALS Society of Canada","keywords":"Amyotrophic lateral sclerosis; Antibody; Genetically modified mouse; Cerebrospinal fluid; Transgene; Spinal cord; Neurodegeneration; Monoclonal antibody; Microglia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001890156,0.0005025783,0.0004277067,0.0003902635,0.0002111176,0.0002553132,0.000185144,0.0004525742,0.001028844],"category_scores_gemma":[0.0001800024,0.0001129273,0.0001913486,0.0001269154,0.0003232978,0.0002641086,0.0001743163,0.0007404432,0.0002273254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002006518,"about_ca_system_score_gemma":0.0004033066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006065805,"about_ca_topic_score_gemma":0.0009379869,"domain_scores_codex":[0.9998717,0.00002375299,0.00001407924,0.00001729213,0.00002848134,0.00004463096],"domain_scores_gemma":[0.9998957,0.00001542651,0.00002674434,0.000008461278,0.00001456324,0.00003911541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001193715,0.0007388222,0.0002070327,0.0001616566,0.00003082112,0.0001783864,0.00004768132,0.0002167858,0.9859121,0.000187136,0.0002184917,0.01090735],"study_design_scores_gemma":[0.0002263321,0.008287028,0.003812831,0.00002973529,0.00007548739,0.000626665,0.000043705,0.001514216,0.9812288,0.0001485714,0.003997322,0.000009406082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948028,0.001984085,0.001274416,0.0002171707,0.0001198018,0.0000492464,0.000124575,0.0001648292,0.001263104],"genre_scores_gemma":[0.9947848,0.001305231,0.0013958,0.00006925799,0.00004975334,0.00003642835,0.0001664417,0.00001125749,0.002181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001028844,"threshold_uncertainty_score":0.003441811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04013907537505696,"score_gpt":0.3307332902045313,"score_spread":0.2905942148294743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}