{"id":"W4414121490","doi":"10.21203/rs.3.rs-7341323/v1","title":"Ultra-early Gamma Knife stereotactic radiosurgery for trigeminal neuralgia (URGEnt-TN): Feasibility and potential benefit: study protocol for a single-centre, two-arm, parallel group design, pragmatic, noninferiority, phase II, randomized controlled trial with intention-to-treat analysis for pre-refractory GK-SRS in classical or idiopathic TN","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Trigeminal Neuralgia and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Radiosurgery; Trigeminal neuralgia; Randomized controlled trial; Incidence (geometry); Clinical trial; Adverse effect; Trigeminal nerve; Intervention (counseling)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009050093,0.003622086,0.0044774,0.0009449846,0.001279085,0.001503012,0.001630957,0.002922324,0.02800265],"category_scores_gemma":[0.006117824,0.00128634,0.002653202,0.0009577359,0.00231661,0.001421903,0.001092986,0.003917487,0.003744739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001649634,"about_ca_system_score_gemma":0.005745306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001146879,"about_ca_topic_score_gemma":0.002476497,"domain_scores_codex":[0.9956005,0.002375013,0.0004386666,0.0005197945,0.0004246641,0.0006414153],"domain_scores_gemma":[0.9978614,0.0005868686,0.00050114,0.000329841,0.0002429197,0.0004777631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9737982,0.005864154,0.0002023466,0.001960326,0.0004697972,0.00004603696,0.00008473278,0.0004316114,0.001929453,0.0006656955,0.001472813,0.0130749],"study_design_scores_gemma":[0.9708211,0.02452251,0.0006098799,0.0001058422,0.0003214177,0.00001813595,0.00001828501,0.0002468186,0.0003478016,0.0003788528,0.002589574,0.00001980419],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.09776951,0.00136192,0.006338751,0.0005539368,0.0007596197,0.8845224,0.003611488,0.0003301301,0.004752307],"genre_scores_gemma":[0.08688685,0.000737779,0.009764421,0.000728071,0.00030798,0.8978856,0.0008161046,0.00003631302,0.002836877],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02800265,"threshold_uncertainty_score":0.09367818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1063788336322254,"score_gpt":0.4453632962284109,"score_spread":0.3389844625961855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}