{"id":"W4414134014","doi":"10.3324/haematol.2025.289055","title":"HLA matching in the PTCy era: the locus still matters. Comment on: Selection of unrelated donors for allogeneic transplantation using post-transplant cyclophosphamide in acute lymphoblastic leukemia: an analysis by the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation","year":2025,"lang":"en","type":"article","venue":"Haematologica","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Cyclophosphamide; Human leukocyte antigen; Transplantation; Lymphoblastic Leukemia; Locus (genetics); Acute leukemia; Selection (genetic algorithm); Acute lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005085894,0.001096389,0.001830409,0.0009897872,0.002689593,0.001503002,0.004180237,0.04904981,0.00739804],"category_scores_gemma":[0.02328162,0.0007034443,0.001839439,0.001245703,0.002682676,0.004352124,0.001435696,0.03523927,0.005010605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002897269,"about_ca_system_score_gemma":0.003808785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01999995,"about_ca_topic_score_gemma":0.02454031,"domain_scores_codex":[0.9967541,0.0006516512,0.0007147007,0.0005057041,0.0009600688,0.0004137443],"domain_scores_gemma":[0.9837074,0.01058391,0.001198427,0.0005015263,0.002380894,0.001627826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001400878,0.00003083032,0.001966456,0.00009869767,0.00002291359,0.001112621,0.0001516909,0.00006213332,0.0002593722,0.001748812,0.9887896,0.005616839],"study_design_scores_gemma":[0.000421424,0.0002594347,0.0130225,0.001271047,0.0002108693,0.004445383,0.001768981,0.0007347676,0.001261687,0.01188123,0.964429,0.0002935761],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0006510213,0.001727288,0.00009488302,0.9753311,0.02096388,0.00001272058,0.0001722336,0.00003331479,0.001013556],"genre_scores_gemma":[0.002820245,0.001182108,0.0001369828,0.9721084,0.02239084,0.00001753253,0.00007312757,0.00001356924,0.001257242],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.04904981,"threshold_uncertainty_score":0.03976709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01386653181090096,"score_gpt":0.2689696260501434,"score_spread":0.2551030942392424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}