{"id":"W4414139555","doi":"10.1002/bimj.70072","title":"Estimands for Early‐Phase Dose Optimization Trials in Oncology","year":2025,"lang":"en","type":"article","venue":"Biometrical Journal","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development","funders":"Newcastle University","keywords":"CLARITY; Clinical trial; Function (biology); Phase (matter); Maximum tolerated dose; Confusion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.212765,0.00202795,0.004297945,0.003164742,0.0008448372,0.006914841,0.00322974,0.003598535,0.005407015],"category_scores_gemma":[0.3908723,0.001505854,0.004579362,0.002889605,0.003956315,0.005753186,0.004726413,0.01034711,0.001333922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004849039,"about_ca_system_score_gemma":0.009097581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002323113,"about_ca_topic_score_gemma":0.002358322,"domain_scores_codex":[0.7458712,0.2343689,0.00508754,0.003605666,0.009976662,0.001089986],"domain_scores_gemma":[0.579576,0.3859304,0.01389039,0.01230922,0.007194912,0.001099152],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001042399,0.0002409275,0.004000978,0.002395486,0.00112198,0.0002698147,0.0005238235,0.1466053,0.0005810042,0.6779605,0.01136085,0.153897],"study_design_scores_gemma":[0.0005628636,0.0007140281,0.001491674,0.002853929,0.0005594685,0.0001250082,0.000150578,0.2796137,0.002004953,0.6767163,0.03506393,0.0001435258],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.002488777,0.00481429,0.9801829,0.004893145,0.0002026325,0.001229773,0.0005412025,0.0003783075,0.005268921],"genre_scores_gemma":[0.1777038,0.005084534,0.7992882,0.004322035,0.0006347539,0.00798037,0.001396497,0.0005034942,0.003086391],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.787235,"threshold_uncertainty_score":0.9708009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8107029982460866,"score_gpt":0.7164979095783318,"score_spread":0.09420508866775479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}