{"id":"W4414139945","doi":"10.1016/j.jacadv.2025.102122","title":"Early Access to Tafamidis for Patients With Transthyretin Amyloid Cardiomyopathy","year":2025,"lang":"en","type":"article","venue":"JACC Advances","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Arena Pharmaceuticals; Pfizer","keywords":"Transthyretin; Clinical trial; Cardiomyopathy; Cohort; Amyloidosis; Amyloid (mycology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008249741,0.0001393694,0.0003476186,0.0002267591,0.0002976825,0.0004544842,0.0001635038,0.0003325437,0.002929512],"category_scores_gemma":[0.001426402,0.0000661653,0.000446685,0.000266073,0.0001341055,0.0003335537,0.0002369717,0.0007449353,0.0003310519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003702336,"about_ca_system_score_gemma":0.0005440449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002599531,"about_ca_topic_score_gemma":0.0009314084,"domain_scores_codex":[0.9996622,0.0001123708,0.00004157129,0.00005434601,0.0000687401,0.0000608213],"domain_scores_gemma":[0.9981703,0.000581896,0.000797566,0.00005039816,0.00009384992,0.0003059482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02184164,0.001706516,0.781901,0.0004776167,0.000266436,0.001883112,0.0002787637,0.0003998252,0.009433199,0.0001870552,0.003560894,0.1780638],"study_design_scores_gemma":[0.003208772,0.02499658,0.9432934,0.0003204347,0.0004426334,0.008799321,0.0002878793,0.001266634,0.004991785,0.0006019849,0.01175883,0.00003171725],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919186,0.004045219,0.0003189231,0.0006652211,0.00003576526,0.0000631932,0.0003741081,0.00002300418,0.002556001],"genre_scores_gemma":[0.9976087,0.0008736781,0.0003168456,0.000350346,0.00009596899,0.00003833453,0.0003795492,0.000003110258,0.000333516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002929512,"threshold_uncertainty_score":0.009800196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0058622494689609,"score_gpt":0.2769787766155609,"score_spread":0.2711165271466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}