{"id":"W4414145598","doi":"10.54254/2753-8818/2025.ld26551","title":"CRISPR/Cas9 Applications in T Cell Modifications for Tumor Immunotherapy","year":2025,"lang":"en","type":"article","venue":"Theoretical and Natural Science","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Immunotherapy; T cell; Immune system; Cancer immunotherapy; T-cell receptor; Cell; Cytokine; Function (biology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005268184,0.0006167335,0.0004343553,0.0006870993,0.0004282799,0.0009495568,0.0004431948,0.001031425,0.002364954],"category_scores_gemma":[0.0004565885,0.0002916607,0.0007494143,0.0004607339,0.000631374,0.0006468207,0.0005797929,0.001276752,0.0008481842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005810169,"about_ca_system_score_gemma":0.0006853986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009811074,"about_ca_topic_score_gemma":0.001087359,"domain_scores_codex":[0.9992724,0.0001274843,0.00007211243,0.0001838762,0.0002644834,0.00007976433],"domain_scores_gemma":[0.9998091,0.00005041071,0.00004705126,0.00002978612,0.00004221974,0.00002145878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001410878,0.00008193772,0.0008139119,0.0008231947,0.00005132859,0.0004614008,0.0001306359,0.002581498,0.912304,0.0103451,0.002531926,0.06973399],"study_design_scores_gemma":[0.00004190435,0.0003794662,0.001321246,0.0000812933,0.0001101236,0.001464385,0.00007774503,0.009916225,0.8865487,0.003583205,0.09642155,0.00005414037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2480011,0.06156432,0.6143826,0.004167286,0.001725632,0.0007872534,0.001442014,0.005158765,0.06277096],"genre_scores_gemma":[0.7935056,0.03238381,0.1497162,0.0013569,0.0002165032,0.000402481,0.001042294,0.0003040118,0.02107215],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002364954,"threshold_uncertainty_score":0.007911563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01105238631440495,"score_gpt":0.3438042944885486,"score_spread":0.3327519081741436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}