{"id":"W4414147897","doi":"10.3892/ijo.2025.5798","title":"Progerin regulates actin cytoskeletal remodeling and inhibits EMT and metastasis in triple‑negative breast cancer cells","year":2025,"lang":"en","type":"article","venue":"International Journal of Oncology","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Basic and Applied Basic Research Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Metastasis; Cytoskeleton; Cell migration; Cell; Lamin; Actin cytoskeleton; Epithelial–mesenchymal transition; Cell adhesion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001688017,0.00007218253,0.000139457,0.0001306809,0.00001966114,0.00001774688,0.00007731123,0.000093281,0.00001447995],"category_scores_gemma":[0.00004493916,0.00006223347,0.0000360633,0.00004800923,0.00005635292,0.00001236811,0.00006987176,0.0001252733,1.940416e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005310194,"about_ca_system_score_gemma":0.0001164693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004116159,"about_ca_topic_score_gemma":0.0001176251,"domain_scores_codex":[0.9994353,0.00005106496,0.000235506,0.0001229166,0.00007809016,0.000077114],"domain_scores_gemma":[0.99956,0.00002213851,0.0001579837,0.00003656978,0.0001936333,0.0000296769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001164895,0.00005265975,0.00285079,0.000009893804,0.0002294241,0.00002029479,0.0001348555,0.00016367,0.7819436,0.0001351242,0.0006134813,0.2126813],"study_design_scores_gemma":[0.00793949,0.001142211,0.07493381,0.0002331489,0.0001541988,0.002045885,0.0008837039,0.001025492,0.8603234,0.003088963,0.04788285,0.0003468352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964753,0.0004481726,0.0002093224,0.001924881,0.0005579043,0.00005807136,0.00001485703,0.000001396534,0.0003101193],"genre_scores_gemma":[0.9975528,0.0006962196,0.001178755,0.0002696466,0.0001885269,0.000002101593,0.000002980797,0.00000520222,0.0001037298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2123345,"threshold_uncertainty_score":0.2537807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006413558375794086,"score_gpt":0.2984307084328789,"score_spread":0.2920171500570848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}