{"id":"W4414152276","doi":"10.1016/bs.ircmb.2025.08.002","title":"Epigenetic regulation of autophagy in cancer: A double-edged sword in tumor progression and therapy resistance","year":2025,"lang":"en","type":"book-chapter","venue":"International review of cell and molecular biology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"CancerCare Manitoba; University of Manitoba","funders":"Organization of Chinese Americans","keywords":"Autophagy; Epigenetics; Crosstalk; Tumor progression; Tumor microenvironment; DNA methylation; Histone; Epigenetic therapy; Precision medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002806281,0.0003655505,0.0006863474,0.0005080124,0.0002715178,0.001381128,0.0005217564,0.0008641878,0.008649982],"category_scores_gemma":[0.0002527664,0.000164603,0.0002926502,0.0008142669,0.0007443485,0.001742707,0.0007278014,0.001906642,0.002922408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005900656,"about_ca_system_score_gemma":0.0005458432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004466544,"about_ca_topic_score_gemma":0.001954806,"domain_scores_codex":[0.9999073,0.00001492063,0.000005261585,0.00001650417,0.00004752016,0.000008530619],"domain_scores_gemma":[0.9999125,0.00004825204,0.000006513305,0.000005929855,0.00001678201,0.000009931309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006621213,0.00004869147,0.000150846,0.001692804,0.00003016387,0.0002509515,0.0002673416,0.0004421167,0.01712162,0.1120946,0.1985611,0.6692737],"study_design_scores_gemma":[0.000006687537,0.0000277991,0.0002560227,0.0003287464,0.00001210275,0.000554962,0.00005961083,0.0001416261,0.001899986,0.01849421,0.9782066,0.00001161821],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00134037,0.9338918,0.005287938,0.0112167,0.005365781,0.00001532979,0.0001360599,0.0001352352,0.04261081],"genre_scores_gemma":[0.009482527,0.8662981,0.005481137,0.006349808,0.004187841,0.00003554161,0.0002049769,0.00007915719,0.1078809],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008649982,"threshold_uncertainty_score":0.02893704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228811077576376,"score_gpt":0.3374727867698695,"score_spread":0.3251846759941057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}