{"id":"W4414153439","doi":"10.1016/j.ebiom.2025.105921","title":"Smouldering disease in paediatric-onset multiple sclerosis","year":2025,"lang":"en","type":"review","venue":"EBioMedicine","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Ottawa Hospital; Hospital for Sick Children; University of Ottawa","funders":"Canadian Institutes of Health Research; Amgen Canada; EMD Serono; National Institutes of Health; Universidad de Chile; Stem Cell Network; National Multiple Sclerosis Society; Horizon Therapeutics; Multiple Sclerosis Society of Canada; Race to Erase MS; Hospital for Sick Children; Ministero della Salute; Multiple Sclerosis Scientific Research Foundation; Fondation Brain Canada; Multiple Sclerosis Society; European Committee for Treatment and Research in Multiple Sclerosis; Bristol-Myers Squibb; Celgene; Fondazione Italiana Sclerosi Multipla; Biogen; Alexion Pharmaceuticals; Patient-Centered Outcomes Research Institute; Neuraxpharm; Johns Hopkins University; Amgen; University of Ottawa; Sanofi","keywords":"Multiple sclerosis; Subclinical infection; Disease; Central nervous system; Magnetic resonance imaging; Central nervous system disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004328793,0.0006918943,0.003060149,0.001684361,0.00007689164,0.00002343578,0.0002858881,0.0005435807,0.0002059051],"category_scores_gemma":[0.001279383,0.0004814328,0.0008257281,0.002226809,0.0001402015,0.0000473507,0.0001769996,0.0007157501,0.0001378053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003861587,"about_ca_system_score_gemma":0.001134982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001073176,"about_ca_topic_score_gemma":0.000005066887,"domain_scores_codex":[0.9963686,0.0001909553,0.001426124,0.0008507899,0.0005727005,0.0005907641],"domain_scores_gemma":[0.9972195,0.0007298006,0.0003466967,0.0009002194,0.00007715582,0.0007266096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008726504,0.000416698,0.005052561,0.08140087,0.0003110338,0.0004061294,0.00004939199,0.000001112015,0.000002458621,0.000003927923,0.01483798,0.8974305],"study_design_scores_gemma":[0.00277903,0.00008247462,0.003792264,0.3803838,0.004746148,0.00003471091,0.00005149512,0.00003218596,5.454249e-7,0.000004740161,0.6076493,0.0004433431],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001845837,0.9953038,0.00001197061,0.0002862962,0.00122868,0.002088358,0.0002487826,0.0001764502,0.0004710477],"genre_scores_gemma":[0.002059363,0.9935524,0.00004950237,0.0002774455,0.0008674075,0.0003941602,0.001042343,0.00008680514,0.001670554],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8969872,"threshold_uncertainty_score":0.9997637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07141800690745097,"score_gpt":0.3256788947267689,"score_spread":0.2542608878193179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}