{"id":"W4414159502","doi":"10.1002/advs.202415285","title":"M2 Macrophages are Major Mediators of Germline Risk of Endometriosis and Explain Pleiotropy With Comorbid Traits","year":2025,"lang":"en","type":"article","venue":"Advanced Science","topic":"Endometriosis Research and Treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia; University of British Columbia Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Cedars-Sinai Medical Center; U.S. Department of Defense","keywords":"Endometriosis; Germline; Transcriptome; Genome-wide association study; Disease; Genetic predisposition; Pleiotropy; Pelvic pain","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004572335,0.0005610019,0.0003115504,0.0007350977,0.0003237234,0.0005420651,0.0002587472,0.0005230239,0.002406389],"category_scores_gemma":[0.001446218,0.0002220877,0.0004119959,0.0005857205,0.0003402341,0.0002019535,0.0006339112,0.0005032432,0.0001851899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001662969,"about_ca_system_score_gemma":0.0002203989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007759535,"about_ca_topic_score_gemma":0.0008804255,"domain_scores_codex":[0.9995286,0.0001755782,0.00002663497,0.0001241274,0.00008093594,0.00006408132],"domain_scores_gemma":[0.9994199,0.0001314572,0.0003010208,0.00005896447,0.00002817633,0.00006045829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001479113,0.0001053921,0.8891715,0.0002865133,0.0007195762,0.002218836,0.0003972847,0.000403499,0.06502599,0.001980004,0.0007314308,0.03748093],"study_design_scores_gemma":[0.000045549,0.0002937505,0.9822676,0.00009800179,0.0003527683,0.004708368,0.0002426051,0.0007703014,0.005397442,0.002563205,0.003235818,0.00002467521],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855935,0.008729217,0.002617086,0.0006052597,0.00003527282,0.00002346161,0.000859583,0.0000433,0.001493335],"genre_scores_gemma":[0.9960371,0.001480698,0.001492184,0.000112003,0.00003587337,0.00002075447,0.0003074993,0.00001225185,0.0005016457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002406389,"threshold_uncertainty_score":0.008050144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006981685567552278,"score_gpt":0.2981515101309916,"score_spread":0.2911698245634393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}