{"id":"W4414160161","doi":"10.1128/spectrum.01131-25","title":"Assembly of the <i>Mycobacterium tuberculosis</i> type VII ESX-1 secretion system in <i>Mycobacterium smegmatis</i> identifies a new transcriptional activator of <i>esx-1</i> genes and a novel TB vaccine","year":2025,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Institute of Nursing Research; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Innovation Saskatchewan; Canadian Institutes of Health Research; National Institutes of Health; National Sanitarium Association","keywords":"Secretion; Operon; Gene; Virulence; Effector; Locus (genetics); Transcription (linguistics); Phenotype; Repressor; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001261417,0.0002629248,0.0002131351,0.0001016268,0.0001276812,0.0003539741,0.0001528106,0.0002438428,0.0004919277],"category_scores_gemma":[0.0001600654,0.0001400388,0.0003688521,0.0001026123,0.0001232861,0.000139408,0.0001742832,0.0003939604,0.0003739346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004683383,"about_ca_system_score_gemma":0.0002137709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006414925,"about_ca_topic_score_gemma":0.0005353719,"domain_scores_codex":[0.9998952,0.00001597099,0.00001249366,0.00002384591,0.00003128808,0.00002117209],"domain_scores_gemma":[0.9999238,0.00001023462,0.00002128871,0.00001215217,0.00001406848,0.00001838474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003098428,0.00001249569,0.0005149567,0.00001943019,0.000002919242,0.00004319464,0.00001600807,0.00006776902,0.9988468,0.00007932747,0.00002737171,0.0003387826],"study_design_scores_gemma":[0.00001549975,0.0001830929,0.01000212,0.00001499476,0.00001878567,0.0003430007,0.00009300924,0.002706388,0.9835593,0.0001099087,0.002947335,0.00000664308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965178,0.0002647674,0.002473964,0.00006186846,0.00002121488,0.00001744303,0.0001904167,0.00003840152,0.0004139528],"genre_scores_gemma":[0.993332,0.0001593628,0.003601227,0.00004085312,0.000007012178,0.00001609488,0.001231766,0.00002051413,0.001591214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006414925,"threshold_uncertainty_score":0.003398061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01124682142608541,"score_gpt":0.2592214324853429,"score_spread":0.2479746110592574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}