{"id":"W4414162578","doi":"10.1371/journal.pgen.1011842","title":"Genome-wide association study provides novel insight into the genetic architecture of severe obesity","year":2025,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; University of Toronto","funders":"Division of Diabetes, Endocrinology, and Metabolic Diseases; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Eunice Kennedy Shriver National Institute of Child Health and Human Development; NHLBI Division of Intramural Research; North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill; National Human Genome Research Institute; National Center for Advancing Translational Sciences; Pediatric Scientist Development Program; National Cancer Institute; National Institute on Aging; National Eye Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute of Child Health and Human Development; U.S. Department of Veterans Affairs","keywords":"Genetic architecture; Obesity; Phenome; Genetic association; Body mass index; Genome-wide association study; Genetic predisposition; Mechanism (biology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004052382,0.0002162772,0.0003069515,0.00007584797,0.000198476,0.0000220887,0.000446107,0.0002579767,0.00000830288],"category_scores_gemma":[0.001115017,0.0001714599,0.000122844,0.0002557839,0.00007716443,0.000001687321,0.0003089038,0.0001843664,0.000005154153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007568744,"about_ca_system_score_gemma":0.0002030691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003890403,"about_ca_topic_score_gemma":0.0005186804,"domain_scores_codex":[0.9982671,0.0002813479,0.0004979855,0.0004130055,0.0002287978,0.0003118017],"domain_scores_gemma":[0.998486,0.000227677,0.0003115343,0.0006251381,0.0002987509,0.00005090286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002233714,0.0004276772,0.9307585,0.00003258198,0.0004321668,4.395293e-7,0.0009107866,0.003959427,0.06249778,0.000009604383,0.0002750015,0.0006737272],"study_design_scores_gemma":[0.0006405227,0.0003566802,0.9738374,0.00001074497,0.00020796,9.080078e-7,0.0003240147,0.0002811918,0.0137989,0.0006493821,0.009694818,0.0001975206],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928239,0.001724101,0.002828825,0.0009318286,0.000141217,0.0008043994,0.00001801891,0.00001285193,0.0007148827],"genre_scores_gemma":[0.9946936,0.0002308155,0.003122448,0.0006691913,0.0001327712,0.00007473343,0.00003590522,0.00002062988,0.001019917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04869888,"threshold_uncertainty_score":0.6991931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01026180615085602,"score_gpt":0.2390667375553695,"score_spread":0.2288049314045135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}