{"id":"W4414162578","doi":"10.1371/journal.pgen.1011842","title":"Genome-wide association study provides novel insight into the genetic architecture of severe obesity","year":2025,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; University of Toronto","funders":"Division of Diabetes, Endocrinology, and Metabolic Diseases; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Eunice Kennedy Shriver National Institute of Child Health and Human Development; NHLBI Division of Intramural Research; North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill; National Human Genome Research Institute; National Center for Advancing Translational Sciences; Pediatric Scientist Development Program; National Cancer Institute; National Institute on Aging; National Eye Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute of Child Health and Human Development; U.S. Department of Veterans Affairs","keywords":"Genetic architecture; Obesity; Phenome; Genetic association; Body mass index; Genome-wide association study; Genetic predisposition; Mechanism (biology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001617177,0.0006077926,0.0006428065,0.001780833,0.0003609408,0.001027481,0.0003988154,0.0005479695,0.002292309],"category_scores_gemma":[0.003110247,0.0003146983,0.001140141,0.002241472,0.0005602639,0.0004618807,0.001104072,0.0009495722,0.0002232848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001543696,"about_ca_system_score_gemma":0.0003598349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001676963,"about_ca_topic_score_gemma":0.00302165,"domain_scores_codex":[0.9988281,0.0003701482,0.0001064111,0.000461565,0.0001461984,0.00008756061],"domain_scores_gemma":[0.9980562,0.0007425928,0.0005491303,0.000407416,0.0001108712,0.0001339227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009230253,0.00006861451,0.9344016,0.0003063255,0.005298363,0.001396879,0.000323291,0.0008965117,0.0211612,0.002007297,0.00117856,0.03203825],"study_design_scores_gemma":[0.0000464808,0.0001131959,0.9874932,0.0000584157,0.001762893,0.00131047,0.0001308072,0.001866341,0.0008512385,0.003370704,0.002968945,0.00002731697],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9666086,0.009586483,0.01633969,0.001018554,0.0001070867,0.00002878807,0.002929665,0.0001954447,0.003185655],"genre_scores_gemma":[0.9940455,0.001412858,0.002934505,0.0002081306,0.0001043286,0.00001531101,0.0009650991,0.00003263795,0.0002816645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002292309,"threshold_uncertainty_score":0.008552551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01026180615085602,"score_gpt":0.2390667375553695,"score_spread":0.2288049314045135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}