{"id":"W4414163940","doi":"10.1016/j.biologicals.2025.101859","title":"Report of the fourth conference on next-generation sequencing (NGS) for adventitious virus detection in biologics for humans and animals: Validation and implementation of NGS","year":2025,"lang":"en","type":"article","venue":"Biologicals","topic":"Animal Virus Infections Studies","field":"Agricultural and Biological Sciences","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"World Health Organization","keywords":"Standardization; Food and drug administration; Guideline; Alliance; Harmonization; Key (lock)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.041023,0.001776142,0.000783082,0.001850077,0.002715518,0.006938123,0.003039288,0.006713113,0.01662215],"category_scores_gemma":[0.01835837,0.0006621119,0.002260381,0.00101061,0.001326432,0.003075649,0.005393603,0.007569084,0.009714754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005303806,"about_ca_system_score_gemma":0.02399513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01144661,"about_ca_topic_score_gemma":0.0130839,"domain_scores_codex":[0.9712649,0.007899403,0.001192447,0.001714933,0.01436783,0.00356046],"domain_scores_gemma":[0.9711492,0.004249929,0.001368885,0.001569187,0.01741057,0.004252277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006731989,0.0006018037,0.003014562,0.002380278,0.0001524946,0.0009483655,0.001435622,0.003553899,0.03010682,0.01098078,0.7276161,0.218536],"study_design_scores_gemma":[0.00004002436,0.0003179582,0.001872134,0.000438388,0.00005453434,0.0001335114,0.0004429177,0.0004698812,0.01647332,0.001572231,0.9780898,0.00009523674],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.04886435,0.06928553,0.1634325,0.2113616,0.1976074,0.0156611,0.01347806,0.00330371,0.2770057],"genre_scores_gemma":[0.126081,0.04233,0.2022914,0.07768007,0.02164172,0.009814293,0.03458673,0.003088992,0.4824858],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.041023,"threshold_uncertainty_score":0.216953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1648539959881057,"score_gpt":0.3434095875946778,"score_spread":0.178555591606572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}