{"id":"W4414167020","doi":"10.1007/s12325-025-03359-5","title":"A Narrative Review of the Immunomodulatory Effects of Acthar® Gel Beyond Its Steroidogenic Properties","year":2025,"lang":"en","type":"article","venue":"Advances in Therapy","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Mallinckrodt Pharmaceuticals","keywords":"Immune system; Narrative review; Rheumatoid arthritis; Adverse effect; Receptor; Melanocortin; Rheumatology; Adrenocorticotropic hormone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000528702,0.0007377484,0.001096572,0.002796732,0.0002663849,0.001225424,0.0005393095,0.0008475152,0.008078263],"category_scores_gemma":[0.001727025,0.0002359448,0.0008788142,0.001810455,0.0002249451,0.001173854,0.0005088099,0.001004894,0.001673729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004858398,"about_ca_system_score_gemma":0.001491367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008996183,"about_ca_topic_score_gemma":0.001747354,"domain_scores_codex":[0.9997014,0.00006303053,0.00008425958,0.00004271298,0.00008960204,0.0000188989],"domain_scores_gemma":[0.9992942,0.0004071965,0.000136474,0.00001037287,0.0001218051,0.00002999512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001811716,0.0000593953,0.0002696632,0.1474814,0.000269656,0.0006793409,0.0002849105,0.0002949077,0.002189955,0.003556756,0.08162495,0.7631078],"study_design_scores_gemma":[0.00002365142,0.0001504921,0.0008774002,0.03212245,0.0004075583,0.002264503,0.0001172104,0.0000686981,0.0003502208,0.0008924948,0.9627026,0.0000228306],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001830755,0.9974903,0.0001107716,0.0004746059,0.0003774547,0.00001923302,0.0000886796,0.000006986043,0.001248897],"genre_scores_gemma":[0.000898317,0.9970119,0.0002588943,0.0005380283,0.0004167887,0.00002656661,0.0001068137,0.000002501966,0.000740049],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008078263,"threshold_uncertainty_score":0.02702451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005476303432366392,"score_gpt":0.255267848729082,"score_spread":0.2497915452967157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}