{"id":"W4414167084","doi":"10.1001/jamaneurol.2025.3217","title":"Plasma Phosphorylated Tau 217 to Identify Preclinical Alzheimer Disease","year":2025,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Center for Diagnosis and Research on Alzheimer's Disease; Alzheimer Society of Canada; Douglas Mental Health University Institute; McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute on Aging; School of Life Sciences and Biotechnology Division of Life Sciences, Korea University; Sahlgrenska Akademin; HORIZON EUROPE Framework Programme; Avid Radiopharmaceuticals; National Institutes of Health; Stichting Dioraphte; Julius Clinical; Grifols; Neuraxpharm; Eli Lilly and Company; BrightFocus Foundation; Hersenstichting; Siemens Healthineers; Göteborgs Universitet; Novo Nordisk; Lunds Universitet; Sorbonne Université; Alzheimer's Association; European Federation of Pharmaceutical Industries and Associations; Australian e-Health Research Centre; Noaber Foundation; Generalitat de Catalunya; Commonwealth Scientific and Industrial Research Organisation; AstraZeneca; European Commission; Genentech; University of Oxford; ZonMw; University of Science and Technology of China; Prothena; Alzheimer Nederland; Cerveau Technologies; School of Medicine and Public Health, University of Wisconsin-Madison; Health~Holland; Biogen; Celgene; University of Melbourne; Faculty of Medicine, McGill University; Canadian Institutes of Health Research; GIESKES-STRIJBIS FONDS; Innovative Health Initiative; Vetenskapsrådet; Eisai; University of Wisconsin-Madison; McGill University; Instituto de Salud Carlos III; European Brain Council; Danone; GHR Foundation; Weston Brain Institute; Bristol-Myers Squibb; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Sanofi","keywords":"Alzheimer's disease; Selection (genetic algorithm); Workflow; Disease; Phosphorylation; Clinical trial; Amyloid β","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001375341,0.0007807513,0.0004040612,0.001312656,0.0003772518,0.0009829117,0.0005497212,0.0007102722,0.001567662],"category_scores_gemma":[0.003401547,0.0002510587,0.0004495155,0.0009962503,0.000365486,0.0005819299,0.0004394722,0.0005300536,0.0006722657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000250519,"about_ca_system_score_gemma":0.0003413752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002027988,"about_ca_topic_score_gemma":0.002976401,"domain_scores_codex":[0.99945,0.0001547652,0.00007987481,0.000142452,0.0001337506,0.0000391016],"domain_scores_gemma":[0.9982108,0.0003217304,0.0008520615,0.0001492516,0.0002968992,0.0001693912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003526127,0.0000561042,0.9945634,0.00002926761,0.0001177973,0.00008779409,0.0000488349,0.0001119863,0.0009203137,0.00001810706,0.0002550918,0.003438706],"study_design_scores_gemma":[0.00002034534,0.000386782,0.996289,0.00002701346,0.00008154124,0.0008346913,0.00009864863,0.0006029836,0.0009753115,0.0001081113,0.0005671539,0.000008436331],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959924,0.0009490274,0.0005573033,0.00007406725,0.00003331933,0.00003680082,0.00122345,0.00001982626,0.001113851],"genre_scores_gemma":[0.9977298,0.0002547226,0.0007094551,0.00004975551,0.00002828392,0.0000274787,0.0007565109,0.000003972865,0.0004400779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002027988,"threshold_uncertainty_score":0.007273614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03380277735439918,"score_gpt":0.3985683284488669,"score_spread":0.3647655510944677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}