{"id":"W4414167871","doi":"10.1016/j.celrep.2025.116288","title":"Evolution of a melanoma that escapes allogeneic rejection","year":2025,"lang":"en","type":"article","venue":"Cell Reports","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; King Abdulaziz University; University College London; Horizon 2020 Framework Programme; UK Research and Innovation; Wellcome Trust; Francis Crick Institute; European Research Council; Cancer Research UK; Ministry of Education – Kingdom of Saudi Arabi; Prince Sattam bin Abdulaziz University","keywords":"Major histocompatibility complex; Melanoma; Downregulation and upregulation; Immune system; MHC class I; Transplantation; Retinoic acid; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002158767,0.0001995905,0.0001219876,0.0002175643,0.0001705071,0.0003123301,0.0001488566,0.0003754366,0.0005780124],"category_scores_gemma":[0.0001454576,0.00009989754,0.0001999311,0.00008464896,0.0001513261,0.0002102769,0.0003210834,0.0005754632,0.0002103762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002555928,"about_ca_system_score_gemma":0.0001641106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003574856,"about_ca_topic_score_gemma":0.0006698336,"domain_scores_codex":[0.9998896,0.00001656386,0.000008129062,0.00002903784,0.00002698495,0.000029726],"domain_scores_gemma":[0.9998895,0.00001168832,0.00003113992,0.00001937677,0.00001394091,0.00003432118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003829773,0.00001891355,0.002257077,0.000008151343,0.000006970545,0.0001503608,0.00002494718,0.0001159289,0.9948211,0.0005311939,0.00002260887,0.002004518],"study_design_scores_gemma":[0.00007464633,0.002204435,0.11522,0.00005101338,0.00007999078,0.01104132,0.0003234669,0.00617101,0.8438324,0.001243077,0.0197216,0.00003710004],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959289,0.0002658803,0.00162739,0.00005169304,0.00001092104,0.00001402237,0.00004764739,0.00003335148,0.002020121],"genre_scores_gemma":[0.995749,0.0002010363,0.001601541,0.00008021129,0.00000452007,0.000008345886,0.0001226218,0.00001608322,0.002216673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005780124,"threshold_uncertainty_score":0.001933634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004316161528041072,"score_gpt":0.247062931837962,"score_spread":0.242746770309921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}