{"id":"W4414181203","doi":"10.1192/j.eurpsy.2025.381","title":"The BDNF/proBDNF ratio as a predictor of antidepressant treatment response in adolescent girls","year":2025,"lang":"en","type":"article","venue":"European Psychiatry","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child, Adolescent and Family Mental Health","funders":"","keywords":"Antidepressant; Depression (economics); Biomarker; Depressive symptoms; Rating scale; Brain-derived neurotrophic factor; Pathophysiology; Pathogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002338592,0.0002188868,0.0002897418,0.0005082319,0.0002016294,0.0003299385,0.0002137638,0.000357315,0.001683033],"category_scores_gemma":[0.001061008,0.0001255971,0.0002718066,0.0003857138,0.0001091085,0.0001482303,0.0001842575,0.0003730948,0.0002226385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001726618,"about_ca_system_score_gemma":0.0001396879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00222821,"about_ca_topic_score_gemma":0.002081076,"domain_scores_codex":[0.9998484,0.00003403418,0.00002553381,0.00003700218,0.00003384822,0.00002116403],"domain_scores_gemma":[0.9994548,0.0001183373,0.0002345308,0.00001486021,0.0000526021,0.0001249551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009734576,0.00002029902,0.9985777,0.000006846031,0.00001156444,0.00007361364,0.00002500685,0.00001096634,0.000263265,0.000004646162,0.00002416899,0.0008846928],"study_design_scores_gemma":[0.000006094296,0.0001092667,0.9989005,0.000007043866,0.00001686826,0.0005183072,0.00009866726,0.0001192118,0.0001159424,0.000007383767,0.00009935154,0.000001240606],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999169,0.0003763484,0.00003048333,0.00003004727,0.00000586526,0.000006239691,0.0001990324,0.000001929007,0.0001811035],"genre_scores_gemma":[0.9994831,0.0001454378,0.0000635121,0.000008554882,0.000004803259,0.000006313885,0.0001934972,9.870353e-7,0.00009377282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00222821,"threshold_uncertainty_score":0.005630314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02020078429301197,"score_gpt":0.2908034052531091,"score_spread":0.2706026209600971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}