{"id":"W4414183311","doi":"10.1038/s41589-025-01998-x","title":"ELOVL6 activity attenuation induces mutant KRAS degradation","year":2025,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"KRAS; Mutant; Gene; Mutation; Signal transduction; Targeted therapy; HEK 293 cells; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001303326,0.000335715,0.0001912919,0.0002064904,0.0001145108,0.0003545408,0.0001992188,0.0003666299,0.002934307],"category_scores_gemma":[0.0001155493,0.0001373882,0.000285601,0.0001187687,0.0002333941,0.0001782662,0.000190094,0.0009292929,0.0008504146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003297256,"about_ca_system_score_gemma":0.0002698952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006367184,"about_ca_topic_score_gemma":0.0009570135,"domain_scores_codex":[0.9997351,0.00002876678,0.00002912537,0.00005156078,0.00007223759,0.00008327819],"domain_scores_gemma":[0.9998541,0.00002177741,0.00004373732,0.00002033563,0.00001353693,0.00004640113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002102989,0.00005394184,0.0001441122,0.00002998275,0.000005950906,0.00006239967,0.000006663517,0.00007227645,0.9978472,0.0001933812,0.0001186293,0.001255091],"study_design_scores_gemma":[0.00001264583,0.0001252799,0.00122033,0.0000033238,0.000005038307,0.0001392474,0.00001487055,0.0004994336,0.9958194,0.00003645625,0.002121873,0.000002115224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909747,0.001053358,0.003142545,0.0003375519,0.000108882,0.00002581933,0.001729535,0.0003046617,0.002322898],"genre_scores_gemma":[0.9913167,0.0003566883,0.00130159,0.00008051771,0.000008218517,0.00002006053,0.001241448,0.00003513736,0.005639664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002934307,"threshold_uncertainty_score":0.009816229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01068264787817372,"score_gpt":0.2751734735762971,"score_spread":0.2644908256981234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}