{"id":"W4414183642","doi":"10.1007/s12668-025-02145-5","title":"Lipid-Polymer Hybrid Nanoparticles for Solubility Enhancement of Tetrahydrocurcumin in a Novel Discriminative Dissolution Medium","year":2025,"lang":"en","type":"article","venue":"BioNanoScience","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Particle size; Dissolution; Bioavailability; Solubility; Zeta potential; Nanoparticle; Drug; Active ingredient; Metabolite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007254675,0.0001634813,0.0002229169,0.0001575658,0.0001743724,0.000006770182,0.0003637087,0.00008665949,0.00008351432],"category_scores_gemma":[0.0002430122,0.0001531576,0.00006970107,0.0004257682,0.0008049075,0.0002089749,0.00008386317,0.0001762106,0.000004657489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002008892,"about_ca_system_score_gemma":0.0002646249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003924953,"about_ca_topic_score_gemma":0.00004511225,"domain_scores_codex":[0.9983291,0.0001058555,0.0004718338,0.000446135,0.0002037287,0.0004433545],"domain_scores_gemma":[0.9990701,0.0004534684,0.0001255128,0.0001790611,0.00009573918,0.00007608755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00028946,0.00116453,0.002409347,0.0001059166,0.00001865931,0.000001074467,0.0006120211,0.0001336579,0.9819831,0.003566631,0.0001863953,0.009529216],"study_design_scores_gemma":[0.001293382,0.0001232288,0.00506182,0.00005851207,0.00003873392,7.848918e-7,0.0001825249,0.005882455,0.9819103,0.0006765801,0.004624991,0.0001466403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9344592,0.0006376547,0.05984177,0.001479441,0.001816533,0.0008991856,0.000196508,0.00002536475,0.0006443355],"genre_scores_gemma":[0.9974781,0.00007459123,0.0007667441,0.0005037474,0.00002887876,0.0002035776,0.00001275872,0.000005880033,0.0009257103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0630189,"threshold_uncertainty_score":0.6245584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08891913556268852,"score_gpt":0.4347344923175582,"score_spread":0.3458153567548697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}