{"id":"W4414189337","doi":"10.1101/2025.09.09.674821","title":"ODC1 restricts meningeal B cell age-associated-like phenotype and function in multiple sclerosis: a human and experimental study","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Macrophage Migration Inhibitory Factor","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; Institute for Clinical Evaluative Sciences; Sunnybrook Health Science Centre","funders":"Multiple Sclerosis Society","keywords":"Meninges; Experimental autoimmune encephalomyelitis; B cell; Multiple sclerosis; Inflammation; Phenotype; Cell; Encephalomyelitis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004721947,0.0005444494,0.0006359636,0.0004349338,0.0003851902,0.0001473139,0.0002448966,0.0007605851,0.00005440625],"category_scores_gemma":[0.0001086803,0.0006177048,0.00006652941,0.000299609,0.0001838238,0.0001207887,0.0006405908,0.0009517157,0.00002058134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002860166,"about_ca_system_score_gemma":0.0001850293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006109113,"about_ca_topic_score_gemma":0.0001656547,"domain_scores_codex":[0.9971683,0.0005281313,0.000626019,0.001111412,0.0001001026,0.0004660487],"domain_scores_gemma":[0.9987096,0.000113264,0.0003748279,0.0005914724,0.0001373297,0.00007355125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001470138,0.001034809,0.07041833,0.00009834864,0.0001517512,0.00002657933,0.0003078011,0.000008073946,0.9273362,0.00002493419,0.0004448197,0.000001394103],"study_design_scores_gemma":[0.0056423,0.0006131848,0.5519915,0.0003647278,0.0001946808,1.317736e-8,0.0002023634,0.00002011173,0.4394732,9.810974e-7,0.0007172783,0.000779685],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911484,0.005668042,0.00002302924,0.00001337031,0.001429207,0.00129856,0.0001720038,0.0002349654,0.00001244607],"genre_scores_gemma":[0.9992149,0.00005477201,0.0001079264,0.0000751075,0.00006295998,0.0003461807,0.000003367963,0.00005371465,0.00008102959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.487863,"threshold_uncertainty_score":0.9996274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02545089640504239,"score_gpt":0.2260958374247703,"score_spread":0.2006449410197279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}