{"id":"W4414194223","doi":"10.1007/s12630-025-03034-x","title":"Local anesthetic dosing for fascial plane blocks to avoid systemic toxicity: a narrative review","year":2025,"lang":"en","type":"review","venue":"Canadian Journal of Anesthesia/Journal canadien d anesthésie","topic":"Myofascial pain diagnosis and treatment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal Jubilee Hospital; University of British Columbia; Queen Elizabeth II Health Sciences Centre; Dalhousie University","funders":"","keywords":"Dosing; Narrative review; Local anesthetic; Epinephrine; Plane (geometry); Local anesthesia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009747982,0.0007823175,0.001577231,0.002008484,0.0002805657,0.00131356,0.0009778105,0.001222765,0.003500365],"category_scores_gemma":[0.00210863,0.000319747,0.0008876226,0.001672133,0.000470457,0.001295234,0.0006863896,0.001638841,0.0008300157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006484978,"about_ca_system_score_gemma":0.001606418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001435603,"about_ca_topic_score_gemma":0.003669792,"domain_scores_codex":[0.9996704,0.00006915155,0.00007828935,0.00006493994,0.00009258161,0.00002468086],"domain_scores_gemma":[0.9991685,0.000556819,0.0001338078,0.00001238233,0.0001030527,0.00002552345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001566265,0.00006798534,0.0002404357,0.08917654,0.0003690179,0.0004282496,0.0001181471,0.0003281684,0.001202572,0.002821784,0.04024128,0.8648493],"study_design_scores_gemma":[0.0001363269,0.0002322199,0.001281645,0.04602796,0.001277874,0.004116092,0.0001594531,0.0001733848,0.0005024137,0.001885784,0.9441524,0.00005439274],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004967604,0.9994247,0.00004831109,0.0001535,0.00009424149,0.000004605391,0.00001215256,0.000001897859,0.0002109003],"genre_scores_gemma":[0.0005205907,0.9986967,0.0001609764,0.0003079369,0.0001233695,0.000006770739,0.00001619622,8.554834e-7,0.0001665411],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003500365,"threshold_uncertainty_score":0.01170993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01454332384771275,"score_gpt":0.273389046817768,"score_spread":0.2588457229700553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}