{"id":"W4414195648","doi":"10.1038/s41416-025-03181-4","title":"Single-cell multiomic modelling of early metastatic events promoted by the extracellular matrix","year":2025,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexen (Canada)","funders":"Ministry of Science and ICT, South Korea; Korea Advanced Institute of Science and Technology; Ministry of Science, ICT and Future Planning; National Research Foundation","keywords":"Extracellular matrix; Metastasis; Carcinogenesis; In vitro; Matrix (chemical analysis); Extracellular","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001450212,0.0003896187,0.0002911998,0.0002788507,0.0001839299,0.0004344263,0.0003869025,0.0006489794,0.0009653521],"category_scores_gemma":[0.0002307486,0.0001798569,0.0005826479,0.0003150639,0.0002771801,0.000244685,0.0002571263,0.0003345528,0.0001535479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003810939,"about_ca_system_score_gemma":0.0003592873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004145277,"about_ca_topic_score_gemma":0.003349274,"domain_scores_codex":[0.9999499,0.000007304129,0.000002388541,0.00001500426,0.00001452868,0.00001087174],"domain_scores_gemma":[0.999894,0.00005020288,0.00001665724,0.000009147491,0.00001652357,0.00001334896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00009979558,0.00009387614,0.00395125,0.0001298395,0.0000417711,0.0002433432,0.00007355763,0.8394205,0.1513494,0.0008453164,0.0002030319,0.003548411],"study_design_scores_gemma":[0.000003693575,0.00004753573,0.002241512,0.000003117551,0.000009982673,0.00003548236,0.00002830924,0.9866454,0.01043812,0.0002677456,0.0002684766,0.00001064236],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9227436,0.0002897371,0.07305215,0.0001099722,0.00002739966,0.00004684663,0.001148496,0.0002135453,0.002368305],"genre_scores_gemma":[0.9799569,0.0002636782,0.01817244,0.00002214938,0.000004872003,0.00008629748,0.0005238567,0.00003337329,0.0009364845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004145277,"threshold_uncertainty_score":0.008242249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02913642206113857,"score_gpt":0.2965186795737028,"score_spread":0.2673822575125642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}