{"id":"W4414199377","doi":"10.1371/journal.ppat.1013507","title":"Proximity labelling reveals VPS13C as a regulator of Salmonella-containing vacuole fission","year":2025,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University Health Network; Princess Margaret Cancer Centre; Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Toronto","keywords":"Biotinylation; Proteome; Vacuole; Intracellular parasite; Intracellular; Cellular compartment; Biotin; Context (archaeology); Regulator","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001689087,0.0001479699,0.0002290768,0.00004987503,0.00012633,0.000007779134,0.0001303145,0.0002529055,0.00001177217],"category_scores_gemma":[0.0001867505,0.0001250117,0.0001079719,0.000144271,0.00006646975,0.000002165345,0.0001514766,0.00011756,0.0000073538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001159946,"about_ca_system_score_gemma":0.00006056482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005985721,"about_ca_topic_score_gemma":0.000002782927,"domain_scores_codex":[0.9990256,0.00006303127,0.0002673084,0.0003178463,0.0001082114,0.0002180464],"domain_scores_gemma":[0.9993967,0.00001730189,0.0001073754,0.0003037353,0.0001246884,0.00005021634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009063906,0.0001065778,0.00908099,0.00009709663,0.000189761,0.000004772652,0.0001231478,0.000009755646,0.9881398,0.0002449002,0.0008755519,0.001037009],"study_design_scores_gemma":[0.0005034326,0.0002652013,0.003498906,0.000287397,0.0001125851,0.000004405134,0.000269596,0.0001398935,0.9901866,0.0005314783,0.004005187,0.0001952736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884948,0.003545906,0.0002257251,0.0002592237,0.0001500683,0.000236266,0.00002334546,0.00002376452,0.007040975],"genre_scores_gemma":[0.9938359,0.0005709862,0.001139269,0.0001875243,0.00007040688,0.0000119056,0.00002799026,0.00001528074,0.004140681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005582084,"threshold_uncertainty_score":0.5097828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009981860289033865,"score_gpt":0.2504897027063439,"score_spread":0.24050784241731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}