{"id":"W4414205557","doi":"10.7150/ijbs.105217","title":"GPX1 expression promotes stemness and aggressiveness in myxoid liposarcomas","year":2025,"lang":"en","type":"article","venue":"International Journal of Biological Sciences","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada","funders":"Agencia Estatal de Investigación; European Regional Development Fund; Instituto de Salud Carlos III; Ministerio de Ciencia e Innovación; Fundación Científica Asociación Española Contra el Cáncer; European Commission; Government of Canada","keywords":"Downregulation and upregulation; GPX1; Sarcoma; Mesenchymal stem cell; Cell culture; Phenotype; Stem cell; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007391282,0.0001490671,0.0001128672,0.0001598106,0.00008552794,0.0001762134,0.00004104578,0.0001267537,0.0004929684],"category_scores_gemma":[0.00005915837,0.00007928428,0.00009256109,0.00007632203,0.0001431827,0.0001226274,0.0001413508,0.0002291027,0.000100474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009822755,"about_ca_system_score_gemma":0.00007378352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001725095,"about_ca_topic_score_gemma":0.0002059021,"domain_scores_codex":[0.9999595,0.000006282211,0.000003035339,0.00001120661,0.00001151321,0.000008447853],"domain_scores_gemma":[0.999958,0.000006895709,0.00001539572,0.00000359458,0.000004330366,0.00001182213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000370708,0.000005408075,0.0005977853,0.000009715689,0.000001582687,0.000029212,0.00001482779,0.00001486969,0.9988349,0.00002920587,0.000006534791,0.0004189374],"study_design_scores_gemma":[0.00001185496,0.0002487648,0.06265836,0.000006306074,0.00001874319,0.0005314883,0.00007330723,0.0008005225,0.9338142,0.0001161594,0.001716511,0.000003885804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989865,0.0003997552,0.00035689,0.00001932454,0.000002062189,0.000003378125,0.0000532361,0.000009216773,0.0001695556],"genre_scores_gemma":[0.998548,0.0002896263,0.0002626937,0.00001072487,0.000002344739,0.00000666428,0.0001425549,0.000002794664,0.0007345391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004929684,"threshold_uncertainty_score":0.001649141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02147595052915693,"score_gpt":0.3466409696123844,"score_spread":0.3251650190832275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}