{"id":"W4414218347","doi":"10.3389/fnins.2025.1618804","title":"FX ENTRAIN: scientific context, study design, and biomarker driven brain-computer interfaces in neurodevelopmental conditions","year":2025,"lang":"en","type":"article","venue":"Frontiers in Neuroscience","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institutes of Health","keywords":"Autism; Intellectual disability; Autism spectrum disorder; Neurodevelopmental disorder; Sensory system; Fragile X syndrome; Biomarker; Sensory processing; Relevance (law); Developmental disorder","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.07303997,0.0008705349,0.00131084,0.0008270532,0.0007157705,0.001496824,0.00110181,0.001424687,0.002818847],"category_scores_gemma":[0.04463823,0.000342309,0.001064095,0.000697783,0.002631424,0.0008550166,0.001375753,0.001392351,0.0004676137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001192349,"about_ca_system_score_gemma":0.003207105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009488626,"about_ca_topic_score_gemma":0.001485227,"domain_scores_codex":[0.9665641,0.02687551,0.002146823,0.001805071,0.002199526,0.0004090124],"domain_scores_gemma":[0.9792792,0.01244077,0.002382082,0.003538146,0.001677634,0.0006822124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.07653253,0.008845602,0.08704083,0.0117839,0.006588968,0.0008424513,0.002020395,0.00818648,0.05507932,0.09410981,0.005845621,0.643124],"study_design_scores_gemma":[0.02338476,0.2067848,0.3336927,0.008446583,0.01156554,0.002349898,0.002184336,0.03971028,0.06372088,0.1804951,0.1272293,0.0004357295],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.5197924,0.06717812,0.3371545,0.01379494,0.005571258,0.03979971,0.001425302,0.0003069006,0.0149768],"genre_scores_gemma":[0.7831864,0.01026248,0.1390621,0.003270678,0.002500952,0.05912837,0.0004093846,0.0001299616,0.00204972],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.07303997,"threshold_uncertainty_score":0.3862769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01342463925299352,"score_gpt":0.2573886884676468,"score_spread":0.2439640492146533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}