{"id":"W4414218852","doi":"10.1136/flgastro-2025-bspghan.29","title":"OC29 Clinical benefits of maralixibat for patients with Alagille syndrome are durable through 7 years of treatment: data from the MERGE study","year":2025,"lang":"en","type":"article","venue":"","topic":"Pediatric Hepatobiliary Diseases and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Alagille syndrome; Merge (version control); Clinical trial; Cholestasis; Bile acid; Abdominal pain; Bilirubin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002780661,0.0004574343,0.001678109,0.0003316973,0.0003702263,0.001208647,0.0005038965,0.001185944,0.006834104],"category_scores_gemma":[0.005626003,0.0001645839,0.003543512,0.0006764885,0.0003188122,0.0007387851,0.0007973208,0.001397943,0.001301169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005354987,"about_ca_system_score_gemma":0.0006958297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001464317,"about_ca_topic_score_gemma":0.004435308,"domain_scores_codex":[0.9982967,0.0006530528,0.0002503881,0.0002114825,0.0003834841,0.0002049376],"domain_scores_gemma":[0.9958549,0.001210192,0.001393461,0.0004196825,0.0004933829,0.0006283529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5084414,0.003463533,0.1300431,0.007845172,0.01780572,0.0006164979,0.0004872872,0.001976042,0.008312153,0.0009389647,0.05111374,0.2689564],"study_design_scores_gemma":[0.1789761,0.06335507,0.6410335,0.001910007,0.01471892,0.001311986,0.0003979825,0.001220039,0.002201075,0.001336367,0.09328963,0.000249245],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8489811,0.05012055,0.0007391221,0.003087741,0.0003269094,0.001270629,0.06849982,0.0002072619,0.02676675],"genre_scores_gemma":[0.9358647,0.00766336,0.0009653267,0.003543257,0.0006029459,0.001032717,0.04609323,0.00006156743,0.004172794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006834104,"threshold_uncertainty_score":0.02286232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06287405152120787,"score_gpt":0.3505278141812265,"score_spread":0.2876537626600186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}