{"id":"W4414226563","doi":"10.1101/2025.09.15.676375","title":"Qualitative Optimization of Oncolytic Virotherapy and Immune Therapy Combination Treatments","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; University of Alberta; Universities Space Research Association","keywords":"Oncolytic virus; Virotherapy; Immunotherapy; Limiting; Immune system; Viral therapy; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005063824,0.0005188924,0.0006211883,0.0003952291,0.0002462939,0.0009567318,0.0005289234,0.0008407596,0.003433991],"category_scores_gemma":[0.001269367,0.0003341604,0.0007069413,0.0003301339,0.0006205444,0.0005662261,0.0004729674,0.0004832328,0.0002370948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001608107,"about_ca_system_score_gemma":0.0007379253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004407262,"about_ca_topic_score_gemma":0.0022068,"domain_scores_codex":[0.9998093,0.00005385126,0.000007629448,0.00003386001,0.00005059085,0.00004486724],"domain_scores_gemma":[0.9996123,0.0002448273,0.00006454252,0.00001955271,0.00004019091,0.00001857787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00003182959,0.00002501296,0.0002258446,0.00006486662,0.00001155362,0.00003414441,0.0000104386,0.9859168,0.005848146,0.005993444,0.0002353614,0.001602501],"study_design_scores_gemma":[0.0000125012,0.00003840334,0.0001965656,0.000009323899,0.00001024086,0.00001226366,0.0000126677,0.9921309,0.003824812,0.00298787,0.0007558863,0.000008561413],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4885884,0.001965648,0.4588952,0.001934887,0.0001259669,0.0002307013,0.002129522,0.0005047007,0.04562502],"genre_scores_gemma":[0.9802697,0.0003238274,0.0145624,0.00008135607,0.000008139994,0.000139228,0.0001780349,0.00005610745,0.00438118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004407262,"threshold_uncertainty_score":0.01166767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02323283066919632,"score_gpt":0.3176844660611479,"score_spread":0.2944516353919516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}