{"id":"W4414229707","doi":"10.1088/1748-605x/ae0777","title":"pH controlled release of extracellular vesicles from a hydrogel scaffold for therapeutic applications","year":2025,"lang":"en","type":"article","venue":"Biomedical Materials","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Extracellular vesicles; Controlled release; Vesicle; Scaffold; Self-healing hydrogels; Microfluidics; Drug delivery; Drug","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003759396,0.0001744319,0.0004166434,0.00006621106,0.00005906653,0.00002053707,0.0003276882,0.0002266971,0.00008723167],"category_scores_gemma":[0.0002338984,0.0001517224,0.000169472,0.0001052182,0.0003025663,0.000003248873,0.00009062233,0.00002785893,0.00001039503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001459363,"about_ca_system_score_gemma":0.0001459777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009546636,"about_ca_topic_score_gemma":8.193809e-7,"domain_scores_codex":[0.998561,0.00009270912,0.0005874527,0.0003892783,0.0001464756,0.000223107],"domain_scores_gemma":[0.9989263,0.0001256387,0.0001956632,0.0005335144,0.0001015761,0.0001173422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009162349,0.0002830183,0.00001827533,0.0001464298,0.0002987767,0.000001570805,0.000009619731,7.981299e-7,0.9911683,0.002818272,0.001258127,0.003080601],"study_design_scores_gemma":[0.003544658,0.0000941426,0.00004372132,0.00005504797,0.0001874135,7.566636e-7,0.00003593133,0.00004008446,0.9476466,0.009837329,0.03837648,0.0001378003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9442669,0.02016912,0.03267329,0.0004354015,0.0003274163,0.001425127,0.0006155942,0.00003047529,0.00005673774],"genre_scores_gemma":[0.9950742,0.0002037873,0.002172723,0.000292863,0.00033107,0.0007630003,0.0006537532,0.0000249485,0.000483621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0508074,"threshold_uncertainty_score":0.6187062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008579913013618337,"score_gpt":0.2663647109397633,"score_spread":0.2577847979261449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}