{"id":"W4414239951","doi":"10.51731/cjht.2025.1224","title":"Osimertinib (Tagrisso)","year":2025,"lang":"en","type":"article","venue":"Canadian Journal of Health Technologies","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Lung cancer; Osimertinib; Exon; Disease; Cancer; Drug; T790M","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002940174,0.0003508412,0.0003314341,0.0005602593,0.0004166845,0.0007869608,0.0004402538,0.000656907,0.03040255],"category_scores_gemma":[0.0004672162,0.00008637354,0.0003509386,0.0005330716,0.0001992228,0.0003434143,0.0004663106,0.0009901196,0.01125895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002453169,"about_ca_system_score_gemma":0.002984829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0171726,"about_ca_topic_score_gemma":0.06331047,"domain_scores_codex":[0.9997892,0.0000147995,0.00001109224,0.00002629494,0.00008565703,0.00007294724],"domain_scores_gemma":[0.9998183,0.000009601838,0.00002158045,0.0000126383,0.00005377102,0.00008417787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00123717,0.0002912289,0.001780411,0.0005209087,0.00005974272,0.0003374104,0.00004389347,0.0004515681,0.006365232,0.004745181,0.3619213,0.622246],"study_design_scores_gemma":[0.001507661,0.0005888156,0.004527582,0.0002013999,0.00004725167,0.001031622,0.00002797909,0.0003610658,0.002777266,0.0008476916,0.9880666,0.000014958],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.07175866,0.09505947,0.002753381,0.02138845,0.003914504,0.001161329,0.02344215,0.002735601,0.7777864],"genre_scores_gemma":[0.401565,0.04828924,0.004726372,0.01676454,0.00103478,0.000588168,0.0444299,0.0002067493,0.4823954],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.03040255,"threshold_uncertainty_score":0.1017066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01814201831550905,"score_gpt":0.3576238266743232,"score_spread":0.3394818083588141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}