{"id":"W4414240166","doi":"10.1159/000548432","title":"Human Apolipoprotein E ε4 Allele Modulates Energy Substrate Availability, Seizure Burden, Mortality and Hippocampal Injury, Cell Death, and Inflammation after Neonatal Hypoxic-Ischemic Brain Injury","year":2025,"lang":"en","type":"article","venue":"Developmental Neuroscience","topic":"Neonatal and fetal brain pathology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Heart, Lung, and Blood Institute","keywords":"Hippocampal formation; Inflammation; Apolipoprotein E; Hippocampus; Allele; Cell; Central nervous system; Programmed cell death","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001315729,0.0002822154,0.0002384114,0.0002819819,0.0001116538,0.000220386,0.0001214918,0.0001727798,0.001061727],"category_scores_gemma":[0.0001463588,0.0001138622,0.0001650884,0.0001689504,0.0002215027,0.0001148779,0.0001728751,0.0002539205,0.0001675136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002245713,"about_ca_system_score_gemma":0.0001668522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009215056,"about_ca_topic_score_gemma":0.001393234,"domain_scores_codex":[0.9998933,0.00001355437,0.00001173544,0.00002849527,0.00002185746,0.00003110443],"domain_scores_gemma":[0.9998534,0.000007594663,0.00007428691,0.000009699345,0.00001515633,0.00003994025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004808036,0.0001711687,0.02146925,0.00005131615,0.00005018193,0.0002281991,0.00007710036,0.00005815236,0.9700556,0.00005257266,0.00009879643,0.002879597],"study_design_scores_gemma":[0.00009676709,0.00247684,0.5071595,0.00003028196,0.0002080657,0.000828637,0.0003652317,0.0006970714,0.4867454,0.0001791828,0.001188778,0.00002413796],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992543,0.0001678027,0.0001978699,0.00001738287,0.000005598968,0.000006071522,0.0001802882,0.000009119538,0.000161538],"genre_scores_gemma":[0.9974263,0.0002811032,0.0002991387,0.0000423152,0.000004249498,0.00003202299,0.0003793468,0.00001024977,0.001525179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001061727,"threshold_uncertainty_score":0.003551841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01580812705038124,"score_gpt":0.2671883867661636,"score_spread":0.2513802597157823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}