{"id":"W4414240166","doi":"10.1159/000548432","title":"Human Apolipoprotein E ε4 Allele Modulates Energy Substrate Availability, Seizure Burden, Mortality and Hippocampal Injury, Cell Death, and Inflammation after Neonatal Hypoxic-Ischemic Brain Injury","year":2025,"lang":"en","type":"article","venue":"Developmental Neuroscience","topic":"Neonatal and fetal brain pathology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Heart, Lung, and Blood Institute","keywords":"Hippocampal formation; Inflammation; Apolipoprotein E; Hippocampus; Allele; Cell; Central nervous system; Programmed cell death","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002945533,0.0003179977,0.0003204308,0.0001863732,0.0002635588,0.00007829649,0.00018226,0.0001568634,0.00002935396],"category_scores_gemma":[0.0001076822,0.0002975732,0.0000460876,0.00035827,0.00062539,0.0003187574,0.0004693093,0.0002633481,0.000006212776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007499024,"about_ca_system_score_gemma":0.000159723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001917146,"about_ca_topic_score_gemma":0.00007082865,"domain_scores_codex":[0.9978737,0.00007297613,0.0004479501,0.0008573515,0.0003178834,0.000430144],"domain_scores_gemma":[0.9993448,0.00003867598,0.0000968647,0.0002525646,0.00005352594,0.0002136222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001414484,0.00004938022,0.05610238,0.0001763113,0.000007349966,0.0001301281,0.0003387064,9.238913e-7,0.9313373,0.0002318131,0.0001593185,0.01132493],"study_design_scores_gemma":[0.0008254886,0.0002404879,0.5626402,0.00006704421,0.00002419575,0.0002620238,0.0001104401,0.0003254557,0.4294147,0.001664284,0.004043741,0.0003819392],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974059,0.000202614,0.0001067544,0.0007552013,0.0001352518,0.0004019211,0.00003896837,0.00007825375,0.0008751581],"genre_scores_gemma":[0.9951457,0.000042772,0.0006663085,0.001722596,0.0000516945,0.00007318299,0.00003835079,0.00001732783,0.002242074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5065379,"threshold_uncertainty_score":0.9999477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01580812705038124,"score_gpt":0.2671883867661636,"score_spread":0.2513802597157823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}