{"id":"W4414249268","doi":"10.1038/s41467-026-71693-5","title":"The genetic basis for DNA methylation variation across tissues and development","year":2025,"lang":"en","type":"preprint","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of Innovation and Advanced Education; Israel Science Foundation","keywords":"DNA methylation; Epigenetics; Methylation; Epigenome; Genetic variation; Differentially methylated regions; Reprogramming; Single-nucleotide polymorphism; RNA-Directed DNA Methylation; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003178404,0.0001241374,0.0002101202,0.000540106,0.0001393845,0.0004530628,0.0002114251,0.0002001815,0.001466464],"category_scores_gemma":[0.0004035645,0.0001672936,0.0001484905,0.0004587404,0.0004532643,0.000203682,0.0004340813,0.0002705003,0.0002344356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001968141,"about_ca_system_score_gemma":0.0001517369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007582682,"about_ca_topic_score_gemma":0.001316162,"domain_scores_codex":[0.9997025,0.00004384093,0.00001356899,0.0001431431,0.00006191248,0.000034869],"domain_scores_gemma":[0.9997827,0.00006495517,0.00006497165,0.00005046109,0.00001684418,0.00002005711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002351002,0.00001179268,0.07899777,0.0000851642,0.0001712598,0.0002021891,0.0001306103,0.001217914,0.8922376,0.004830783,0.00031093,0.02156893],"study_design_scores_gemma":[0.00001432005,0.0001046602,0.7843351,0.00002239614,0.0001563069,0.001167114,0.0001576236,0.005861373,0.1870698,0.01373964,0.007341278,0.00003033609],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9667374,0.001273829,0.02577989,0.000174659,0.0000222361,0.00001018428,0.002302144,0.0002688633,0.003430836],"genre_scores_gemma":[0.9954141,0.0002494833,0.003076781,0.00005098741,0.000008440395,0.000005755377,0.0004157239,0.00004281377,0.0007358948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001466464,"threshold_uncertainty_score":0.00490576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02639340126226686,"score_gpt":0.353912808204587,"score_spread":0.3275194069423201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}