{"id":"W4414249926","doi":"10.1111/hae.70128","title":"The Critical Need to Consolidate All Gene Therapy Data in Haemophilia","year":2025,"lang":"en","type":"letter","venue":"Haemophilia","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Hemophilia Society","funders":"","keywords":"Haemophilia; Clinical trial; Genetic enhancement; Dosing; Haemophilia A; Haemophilia B; Milestone; Targeted therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04617428,0.00139547,0.00504868,0.005347487,0.001900846,0.01442083,0.004472703,0.01182165,0.02287886],"category_scores_gemma":[0.09699327,0.0009336775,0.002139495,0.004442777,0.006109401,0.02536404,0.006905384,0.02410349,0.0103188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004786407,"about_ca_system_score_gemma":0.01465894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002181813,"about_ca_topic_score_gemma":0.003648199,"domain_scores_codex":[0.9844112,0.006117852,0.001995074,0.001411598,0.005469295,0.0005950038],"domain_scores_gemma":[0.8134681,0.09949957,0.008585831,0.01164192,0.05222361,0.01458108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005569443,0.0002505039,0.001170232,0.007364595,0.0002807822,0.0002353741,0.0002770319,0.0004076876,0.002064629,0.0344717,0.359883,0.5930376],"study_design_scores_gemma":[0.00006536684,0.0003015121,0.0007406623,0.006215362,0.0001644245,0.0004131685,0.0002384902,0.0002147648,0.0005265531,0.01839804,0.9726692,0.00005232395],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.0008802176,0.58568,0.00658639,0.3694521,0.03016293,0.00009326874,0.001064241,0.0004330621,0.005647842],"genre_scores_gemma":[0.009970114,0.6458226,0.02542751,0.2258029,0.0853847,0.0002408688,0.002690409,0.0004597533,0.004201065],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.04617428,"threshold_uncertainty_score":0.2441958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1061445736345884,"score_gpt":0.3954813158247728,"score_spread":0.2893367421901843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}