{"id":"W4414257148","doi":"10.1136/jitc-2025-012496","title":"MAIT cells promote cancer progression and regulatory T cell accumulation in bladder tumor microenvironment","year":2025,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Government of Ontario; Cancer Research Society","keywords":"Tumor microenvironment; Regulatory T cell; T cell; Bladder cancer; Tumor cells; Cell; Tumor progression; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002167012,0.0002270001,0.0002776024,0.0004697217,0.0002107088,0.0004431621,0.0001003773,0.0002130931,0.002053171],"category_scores_gemma":[0.0003471953,0.0001536602,0.00021494,0.0003138483,0.0002272864,0.000177778,0.0003014306,0.0007410747,0.0003845955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001715117,"about_ca_system_score_gemma":0.0002186582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003387716,"about_ca_topic_score_gemma":0.0004569721,"domain_scores_codex":[0.9997664,0.0000274477,0.00001661855,0.00007546315,0.00005008511,0.00006406209],"domain_scores_gemma":[0.9995796,0.00005512626,0.0001466175,0.00003528087,0.00004265632,0.0001408058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001058203,0.00008275377,0.01754765,0.0002026092,0.00002408959,0.0001601993,0.000130278,0.0004685964,0.97142,0.0001631955,0.0003088126,0.008433582],"study_design_scores_gemma":[0.0001364054,0.002338263,0.2873994,0.00009867758,0.0002518219,0.001969496,0.0005225869,0.00942713,0.6757002,0.000739196,0.02137859,0.00003833865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941714,0.001719558,0.002199174,0.00006256714,0.00002177164,0.00003075666,0.0008139381,0.000156315,0.0008243868],"genre_scores_gemma":[0.9958171,0.0005315535,0.001665158,0.00006969739,0.0000300472,0.00005083313,0.0008718692,0.0000274346,0.0009362385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002053171,"threshold_uncertainty_score":0.006868541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01115777216153967,"score_gpt":0.3116410995756,"score_spread":0.3004833274140604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}