{"id":"W4414268162","doi":"10.1038/s41557-025-01930-9","title":"Tumour-specific STING agonist synthesis via a two-component prodrug system","year":2025,"lang":"en","type":"article","venue":"Nature Chemistry","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Alzheimer’s Research UK","keywords":"Prodrug; Moiety; Agonist; Sting; Dimer; Chemical synthesis; Covalent bond; Antagonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002459279,0.0002627801,0.0003586281,0.00006079027,0.0002876872,0.00004063871,0.0004151151,0.0006064363,0.0003357706],"category_scores_gemma":[0.0001568952,0.0002328634,0.0001589627,0.0001368073,0.0001477972,0.00003639829,0.0001392465,0.001200035,0.0002391999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002207159,"about_ca_system_score_gemma":0.00009346119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001584388,"about_ca_topic_score_gemma":8.298357e-7,"domain_scores_codex":[0.9986889,0.000114177,0.0003365418,0.0004229229,0.00004657745,0.0003908179],"domain_scores_gemma":[0.999057,0.0002741559,0.0001189313,0.0004366899,0.00009290445,0.00002030453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003866028,0.00007704749,0.00005651801,0.0003102459,0.0001547915,0.00001945895,0.00004738097,0.000001096774,0.9879807,0.0003406942,0.008445812,0.002179713],"study_design_scores_gemma":[0.0005201499,0.000007572379,0.0002596236,0.0004952024,0.00004076895,0.0001768746,0.0004011882,0.000007785823,0.9184256,0.000008297434,0.07946283,0.0001940947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.885831,0.03594357,0.0002218364,0.0008434666,0.002256211,0.0003334538,0.00005328132,0.0004983871,0.07401881],"genre_scores_gemma":[0.9884108,0.0000251199,0.00005095907,0.0001008137,0.00007683015,0.00005171375,0.00005632327,0.00001961906,0.01120781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1025798,"threshold_uncertainty_score":0.9495893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004420284166327814,"score_gpt":0.2290270457968064,"score_spread":0.2246067616304786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}