{"id":"W4414272675","doi":"10.1101/2025.09.17.675183","title":"Early micro and nanoscopic responses of microglia to blood-brain barrier modulation by transcranial-focused ultrasound","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Photoacoustic and Ultrasonic Imaging","field":"Engineering","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Victoria","funders":"FDC Foundation; Sunnybrook Foundation","keywords":"Microglia; Hippocampal formation; Microbubbles; Blood–brain barrier; Ultrasound; Inflammation; Permeability (electromagnetism); Immunofluorescence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001213649,0.0002435333,0.0001750041,0.0001952688,0.0001048154,0.0001514388,0.00007473026,0.0002669824,0.0006388224],"category_scores_gemma":[0.00009100723,0.0001038975,0.0001787883,0.0000823563,0.0002264156,0.0001626664,0.0001398426,0.0002981227,0.0001599395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001775229,"about_ca_system_score_gemma":0.00008773243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003823482,"about_ca_topic_score_gemma":0.0005914171,"domain_scores_codex":[0.9999104,0.000009841016,0.000005078645,0.00001801003,0.0000238289,0.00003279972],"domain_scores_gemma":[0.9999472,0.00001051477,0.00001763625,0.000004291661,0.000009948461,0.00001040685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001463325,0.00001093626,0.0001731022,0.00002772418,0.000002437148,0.00004158989,0.00002180519,0.00002125999,0.9987883,0.00002658193,0.00001355028,0.0007264225],"study_design_scores_gemma":[0.00001875559,0.0006560673,0.0199245,0.000009926142,0.00001728189,0.0002312549,0.00008999767,0.0004228301,0.9776789,0.00008966458,0.0008548005,0.000006055185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937337,0.002022229,0.003004451,0.00004291623,0.00002116043,0.00003335855,0.0001864011,0.00004674444,0.000908907],"genre_scores_gemma":[0.9952292,0.0008701201,0.002450555,0.00005128494,0.00001756409,0.0000841725,0.0001332038,0.000007060175,0.001156859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006388224,"threshold_uncertainty_score":0.002137065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005433096223151346,"score_gpt":0.1958407989002133,"score_spread":0.1904077026770619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}