{"id":"W4414273333","doi":"10.1101/2025.09.14.676084","title":"A validated antibody toolbox for ALS research","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium; Montreal Neurological Institute and Hospital","funders":"Motor Neurone Disease Association; National Centre for the Replacement, Refinement and Reduction of Animals in Research; Génome Québec; ALS Society of Canada; Genome Canada; University of Washington","keywords":"Amyotrophic lateral sclerosis; Antibody; Disease; Toolbox; Gene; Human disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007753347,0.001777761,0.001069083,0.00220078,0.0007163935,0.001816035,0.001660357,0.001367348,0.006509359],"category_scores_gemma":[0.005654621,0.0008059749,0.001005393,0.001145843,0.0007601815,0.001326888,0.002201307,0.002041966,0.007785106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009916079,"about_ca_system_score_gemma":0.001555094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007055104,"about_ca_topic_score_gemma":0.0008697871,"domain_scores_codex":[0.995865,0.0009966734,0.0004721447,0.0006950162,0.001692826,0.0002783559],"domain_scores_gemma":[0.9956027,0.000755265,0.0004682305,0.001121112,0.00173725,0.0003154757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002511486,0.000118644,0.001005458,0.0004023783,0.00007036536,0.0001468826,0.00006927346,0.001050535,0.9654723,0.002694156,0.006647849,0.02207105],"study_design_scores_gemma":[0.00007873265,0.0003858367,0.002419651,0.000106467,0.0001017328,0.0007037587,0.00003434536,0.004828328,0.8828225,0.002220786,0.1062455,0.00005235879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1245384,0.005735289,0.8066372,0.001528885,0.0006758444,0.00160443,0.02273977,0.02170714,0.01483301],"genre_scores_gemma":[0.190673,0.003855478,0.7198553,0.001352184,0.0002586124,0.002775736,0.0618837,0.004778007,0.01456802],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.007753347,"threshold_uncertainty_score":0.04100406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0783529083396564,"score_gpt":0.3786783326805397,"score_spread":0.3003254243408833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}