{"id":"W4414284840","doi":"10.1128/msphere.00423-25","title":"A nitric oxide-sensing two-component system regulates a range of infection-related phenotypes in <i>Burkholderia pseudomallei</i>","year":2025,"lang":"en","type":"article","venue":"mSphere","topic":"Burkholderia infections and melioidosis","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council Canada; Leverhulme Trust","keywords":"Autophosphorylation; Biofilm; Virulence; Regulator; Histidine kinase; Phenotype; Phosphorylation; Signal transduction; Nitric oxide","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013547,0.0002317527,0.0001331143,0.0001395868,0.0001601037,0.0002384956,0.0001749551,0.0001897366,0.0004542094],"category_scores_gemma":[0.0001376096,0.00008240155,0.000142602,0.00007314504,0.0001646046,0.0001116776,0.0001812155,0.0002801212,0.0001924094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003035302,"about_ca_system_score_gemma":0.0001153094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008988052,"about_ca_topic_score_gemma":0.0006629321,"domain_scores_codex":[0.9998752,0.00002892513,0.000008909714,0.00002771854,0.00002815442,0.00003108387],"domain_scores_gemma":[0.9998659,0.00002399856,0.00004708711,0.0000131457,0.00002035811,0.00002948857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005584333,0.00001645603,0.0004241336,0.00000883693,0.000001607574,0.00001865835,0.000007369876,0.00002162713,0.9991667,0.00002650731,0.00001557139,0.0002367472],"study_design_scores_gemma":[0.00002802019,0.0004336527,0.07859698,0.000009568637,0.00001843021,0.000357151,0.0001311118,0.005055543,0.9137128,0.0001453734,0.001499706,0.00001174313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978613,0.0004089114,0.00101637,0.00007877473,0.00001258614,0.00001127493,0.0001612217,0.00003789076,0.0004115445],"genre_scores_gemma":[0.9986259,0.00008836143,0.0005984961,0.00004078357,0.00000265725,0.00001567627,0.0002258334,0.000004929247,0.0003975127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008988052,"threshold_uncertainty_score":0.002202332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008808435402788148,"score_gpt":0.2469884931766841,"score_spread":0.238180057773896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}