{"id":"W4414286893","doi":"10.14740/wjon2631","title":"Problems in Cancer Genome Medicine: Base Mutations Cause Intron Start Signals, Resulting in Unexpected Splicing","year":2025,"lang":"en","type":"article","venue":"World Journal of Oncology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Chugai Pharmaceutical; University of Tokyo; Sysmex Corporation","keywords":"Gene; RNA splicing; Cancer; Intron; Mutation; Genome; Genetic testing","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001586275,0.0007013171,0.0004486007,0.001551122,0.0006836604,0.0007777624,0.0007278319,0.002074388,0.002515983],"category_scores_gemma":[0.004487192,0.0002599497,0.0003561146,0.001288197,0.001097298,0.0007084649,0.0004407997,0.001012816,0.001191042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003333611,"about_ca_system_score_gemma":0.000331442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004967987,"about_ca_topic_score_gemma":0.000574613,"domain_scores_codex":[0.9986267,0.0003474067,0.0001750032,0.0003728322,0.0003676035,0.0001104043],"domain_scores_gemma":[0.9970374,0.001496842,0.0007670192,0.0002185703,0.0003194374,0.0001607706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008776208,0.0003260701,0.3407442,0.001363942,0.0003938694,0.1553923,0.002365426,0.001919717,0.2746276,0.009056643,0.01236822,0.2005643],"study_design_scores_gemma":[0.0001264064,0.000778042,0.1341515,0.0004578699,0.0006421023,0.5853474,0.001833414,0.00623631,0.1865977,0.01585615,0.06784493,0.0001283201],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.886775,0.02682785,0.05637137,0.0106599,0.001408051,0.0001808196,0.0009549931,0.001497131,0.01532486],"genre_scores_gemma":[0.9568728,0.005905833,0.02823194,0.00449968,0.0006262551,0.00005024091,0.0006287835,0.0002386679,0.002945801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002515983,"threshold_uncertainty_score":0.008416772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04506725641101516,"score_gpt":0.3725143874040672,"score_spread":0.327447130993052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}